Retromer retrieves wntless - PubMed (original) (raw)

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Retromer retrieves wntless

Suzanne Eaton. Dev Cell. 2008 Jan.

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Abstract

Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.

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• Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.
  Yang PT, Lorenowicz MJ, Silhankova M, Coudreuse DY, Betist MC, Korswagen HC. Yang PT, et al. Dev Cell. 2008 Jan;14(1):140-7. doi: 10.1016/j.devcel.2007.12.004. Epub 2007 Dec 20. Dev Cell. 2008. PMID: 18160347
• The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network.
  Belenkaya TY, Wu Y, Tang X, Zhou B, Cheng L, Sharma YV, Yan D, Selva EM, Lin X. Belenkaya TY, et al. Dev Cell. 2008 Jan;14(1):120-31. doi: 10.1016/j.devcel.2007.12.003. Epub 2007 Dec 20. Dev Cell. 2008. PMID: 18160348

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