Mechanisms of inherited cancer susceptibility - PubMed (original) (raw)

Review

Mechanisms of inherited cancer susceptibility

Shirley Hodgson. J Zhejiang Univ Sci B. 2008 Jan.

Abstract

A small proportion of many cancers are due to inherited mutations in genes, which result in a high risk to the individual of developing specific cancers. There are several classes of genes that may be involved: tumour suppressor genes, oncogenes, genes encoding proteins involved in DNA repair and cell cycle control, and genes involved in stimulating the angiogenic pathway. Alterations in susceptibility to cancer may also be due to variations in genes involved in carcinogen metabolism. This review discusses examples of some of these genes and the associated clinical conditions caused by the inheritance of mutations in such genes.

PubMed Disclaimer

Similar articles

• [Genetic factors involved in cancer susceptibility].
  Kohno T, Yokota J. Kohno T, et al. Gan To Kagaku Ryoho. 2002 Jul;29(7):1255-62. Gan To Kagaku Ryoho. 2002. PMID: 12146010 Review. Japanese.
• Cancer genetics.
  Knudson AG. Knudson AG. Am J Med Genet. 2002 Jul 22;111(1):96-102. doi: 10.1002/ajmg.10320. Am J Med Genet. 2002. PMID: 12124744 Review.
• [Disruption of mismatch repair system in human cancers].
  Fukushige S, Horii A. Fukushige S, et al. Nihon Rinsho. 1996 Apr;54(4):1002-7. Nihon Rinsho. 1996. PMID: 8920664 Review. Japanese.
• [Genetics and cancer: advances and perspectives].
  Kahn A. Kahn A. Pathol Biol (Paris). 1995 Mar;43(3):139-42. Pathol Biol (Paris). 1995. PMID: 7675539 Review. French.

Cited by

• Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era.
  Neagu AN, Bruno P, Johnson KR, Ballestas G, Darie CC. Neagu AN, et al. Int J Mol Sci. 2024 Apr 8;25(7):4113. doi: 10.3390/ijms25074113. Int J Mol Sci. 2024. PMID: 38612922 Free PMC article. Review.
• Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression.
  Perriera R, Vitale E, Pibiri I, Carollo PS, Ricci D, Corrao F, Fiduccia I, Melfi R, Zizzo MG, Tutone M, Pace A, Lentini L. Perriera R, et al. Int J Mol Sci. 2023 Oct 11;24(20):15084. doi: 10.3390/ijms242015084. Int J Mol Sci. 2023. PMID: 37894764 Free PMC article.
• Multilocus Inherited Neoplasia Allele Syndrome (MINAS): an update.
  McGuigan A, Whitworth J, Andreou A, Hearn T; Genomics England Research Consortium; Tischkowitz M, Maher ER. McGuigan A, et al. Eur J Hum Genet. 2022 Mar;30(3):265-270. doi: 10.1038/s41431-021-01013-6. Epub 2022 Jan 4. Eur J Hum Genet. 2022. PMID: 34983940 Free PMC article. Review.
• MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition.
  Afgar A, Fard-Esfahani P, Mehrtash A, Azadmanesh K, Khodarahmi F, Ghadir M, Teimoori-Toolabi L. Afgar A, et al. Cancer Biol Ther. 2016 Nov;17(11):1126-1138. doi: 10.1080/15384047.2016.1235657. Epub 2016 Sep 26. Cancer Biol Ther. 2016. PMID: 27668319 Free PMC article.
• Determination of Pathogenicity of Breast Cancer 1 Gene Variants using the American College of Medical Genetics and Genomics and the Association for Molecular Pathology Guidelines.
  Brown A, Zamanpoor M, Love DR, Prosser DO. Brown A, et al. Sultan Qaboos Univ Med J. 2019 Nov;19(4):e324-e334. doi: 10.18295/squmj.2019.19.04.008. Epub 2019 Dec 22. Sultan Qaboos Univ Med J. 2019. PMID: 31897316 Free PMC article.

References

1. 1. Antoniou A, Pharoah PDP, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, et al. Average risks of breast and ovarian cancer associated with BRCA1 and BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet. 2003;72(5):1117–1130. doi: 10.1086/375033. - DOI - PMC - PubMed
2. 1. Bandipalliam P, Garber J, Kolodner RD, Syngal S. Clinical presentation correlates with the type of mismatch repair gene involved in Hereditary Nonpolyposis Colon Cancer. Gastroenterology. 2004;126(3):936–937. doi: 10.1053/j.gastro.2004.01.038. - DOI - PubMed
3. 1. Eng C, Mulligan LM, Healey CS, Houghton C, Frilling A, Raue F, Thomas GA, Ponder BAJ. Heterogeneous mutation of the RET proto-oncogene in subpopulation of medullary thyroid carcinoma. Cancer Res. 1996;56:2167–2170. - PubMed
4. 1. Heiskanen I, Luostarinen T, Järvinen HJ. Impact of screening examinations on survival in familial adenomatous polyposis. Scand J Gastroenterol. 2000;35(12):1284–1287. doi: 10.1080/003655200453638. - DOI - PubMed
5. 1. Hodgson SV, Foulkes W, Eng C, et al. A Practical Guide to Inherited Cancer Susceptibility. UK: Cambridge University Press; 2007.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central
  • Zhejiang University Press