Viruses associated with human cancer - PubMed (original) (raw)
Review
Viruses associated with human cancer
Margaret E McLaughlin-Drubin et al. Biochim Biophys Acta. 2008 Mar.
Abstract
It is estimated that viral infections contribute to 15-20% of all human cancers. As obligatory intracellular parasites, viruses encode proteins that reprogram host cellular signaling pathways that control proliferation, differentiation, cell death, genomic integrity, and recognition by the immune system. These cellular processes are governed by complex and redundant regulatory networks and are surveyed by sentinel mechanisms that ensure that aberrant cells are removed from the proliferative pool. Given that the genome size of a virus is highly restricted to ensure packaging within an infectious structure, viruses must target cellular regulatory nodes with limited redundancy and need to inactivate surveillance mechanisms that would normally recognize and extinguish such abnormal cells. In many cases, key proteins in these same regulatory networks are subject to mutation in non-virally associated diseases and cancers. Oncogenic viruses have thus served as important experimental models to identify and molecularly investigate such cellular networks. These include the discovery of oncogenes and tumor suppressors, identification of regulatory networks that are critical for maintenance of genomic integrity, and processes that govern immune surveillance.
Figures
Figure 1
Schematic depiction of the major biological activities that contribute to the transforming activities of HTLV-1. See text for details.
Figure 2
Schematic depiction of the major biological activities that contribute to the transforming activities of HCV. See text for details.
Figure 3
Schematic depiction of the major biological activities that contribute to the transforming activities of high-risk mucosal HPVs. See text for details.
Figure 4
Schematic depiction of the major biological activities that contribute to the transforming activities of HBV. See text for details.
Figure 5
Schematic depiction of the major biological activities that contribute to the transforming activities of EBV. See text for details.
Figure 6
Schematic depiction of the major biological activities that contribute to the transforming activities of HHV-8/KSHV. See text for details.
Similar articles
- Epigenetic Alterations in Human Papillomavirus-Associated Cancers.
Soto D, Song C, McLaughlin-Drubin ME. Soto D, et al. Viruses. 2017 Sep 1;9(9):248. doi: 10.3390/v9090248. Viruses. 2017. PMID: 28862667 Free PMC article. Review. - Molecular mechanisms of virus-induced carcinogenesis: the interaction of viral factors with cellular tumor suppressor proteins.
Hoppe-Seyler F, Butz K. Hoppe-Seyler F, et al. J Mol Med (Berl). 1995 Nov;73(11):529-38. doi: 10.1007/BF00195138. J Mol Med (Berl). 1995. PMID: 8751137 Review. - Viral carcinogenesis and genomic instability.
Münger K, Hayakawa H, Nguyen CL, Melquiot NV, Duensing A, Duensing S. Münger K, et al. EXS. 2006;(96):179-99. doi: 10.1007/3-7643-7378-4_8. EXS. 2006. PMID: 16383019 Review. - [Oncogenic viruses and their role in tumour formation].
Cupić M, Lazarević I, Kuljić-Kapulica N. Cupić M, et al. Srp Arh Celok Lek. 2005 Jul-Aug;133(7-8):384-7. doi: 10.2298/sarh0508384c. Srp Arh Celok Lek. 2005. PMID: 16623266 Review. Serbian. - Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease.
Butel JS. Butel JS. Carcinogenesis. 2000 Mar;21(3):405-26. doi: 10.1093/carcin/21.3.405. Carcinogenesis. 2000. PMID: 10688861 Review.
Cited by
- Associations of head and neck cancers with herpes zoster in the preceding five years.
Chen CH, Xirasagar S, Hung SH, Lin HC, Chen CS. Chen CH, et al. Sci Rep. 2024 Sep 15;14(1):21541. doi: 10.1038/s41598-024-72893-z. Sci Rep. 2024. PMID: 39278971 Free PMC article. - Evaluating the Expression Levels of Human Endogenous Retrovirus-K 10 (HERV-K10) Gag as a Biomarker in Prostate Cancer Tissue.
Ouariagli I, Alaoui Sosse S, Laraqui A, Tagajdid MR, Mrabti M, Alami M, Ennaji MM. Ouariagli I, et al. Cureus. 2024 Jul 10;16(7):e64275. doi: 10.7759/cureus.64275. eCollection 2024 Jul. Cureus. 2024. PMID: 39130945 Free PMC article. - The Microbiome Matters: Its Impact on Cancer Development and Therapeutic Responses.
Chung IY, Kim J, Koh A. Chung IY, et al. J Microbiol. 2024 Mar;62(3):137-152. doi: 10.1007/s12275-024-00110-7. Epub 2024 Apr 8. J Microbiol. 2024. PMID: 38587593 Review. - Revolutionizing Antiviral Therapeutics: Unveiling Innovative Approaches for Enhanced Drug Efficacy.
Megantara S, Rusdin A, Budiman A, Shamsuddin S, Mohtar N, Muchtaridi M. Megantara S, et al. Int J Nanomedicine. 2024 Mar 20;19:2889-2915. doi: 10.2147/IJN.S447721. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38525012 Free PMC article. Review. - Epigenetic and Genetic Keys to Fight HPV-Related Cancers.
Folliero V, Dell'Annunziata F, Chianese A, Morone MV, Mensitieri F, Di Spirito F, Mollo A, Amato M, Galdiero M, Dal Piaz F, Pagliano P, Rinaldi L, Franci G. Folliero V, et al. Cancers (Basel). 2023 Nov 25;15(23):5583. doi: 10.3390/cancers15235583. Cancers (Basel). 2023. PMID: 38067286 Free PMC article. Review.
References
- Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108. - PubMed
- zur Hausen H. Viruses in human cancers. Current Science. 2001;81:523–27.
- Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118:3030–44. - PubMed
- M’Fadyan J, Hobday F. Note on the experimental “transmission of warts in the dog”. J Comp Pathol Ther. 1898;11:341–43.
- Ciuffo G. Innesto positivo con filtrato di verruca volgare. Giorn Ital Mal Venereol. 1907;48:12–17.
Publication types
MeSH terms
Grants and funding
- R01 CA066980-12/CA/NCI NIH HHS/United States
- CA081135/CA/NCI NIH HHS/United States
- R01 CA081135-10/CA/NCI NIH HHS/United States
- R01 CA066980/CA/NCI NIH HHS/United States
- R01 CA081135/CA/NCI NIH HHS/United States
- CA066980/CA/NCI NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials