Synaptic adhesion molecules and PSD-95 - PubMed (original) (raw)
Review
Synaptic adhesion molecules and PSD-95
Kihoon Han et al. Prog Neurobiol. 2008 Mar.
Abstract
Synaptic adhesion molecules are known to participate in various steps of synapse development including initial contacts between dendrites and axons, formation of early synapses, and their maturation and plastic changes. Notably, a significant subset of synaptic adhesion molecules associates with synaptic scaffolding proteins, suggesting that they may act in concert to couple trans-synaptic adhesion to molecular organization of synaptic proteins. Here, we describe an emerging group of synaptic adhesion molecules that directly interact with the abundant postsynaptic scaffold PSD-95, which include neuroligins, NGLs, SALMs, and ADAM22, and discuss how these proteins and PSD-95 act together to regulate synaptic development. PSD-95 may be one of the central organizers of synaptic adhesion that recruits diverse proteins to sites of synaptic adhesion, promotes trans-synaptic signaling, and couples neuronal activity with changes in synaptic adhesion.
Similar articles
- The NGL family of leucine-rich repeat-containing synaptic adhesion molecules.
Woo J, Kwon SK, Kim E. Woo J, et al. Mol Cell Neurosci. 2009 Sep;42(1):1-10. doi: 10.1016/j.mcn.2009.05.008. Epub 2009 May 23. Mol Cell Neurosci. 2009. PMID: 19467332 Review. - Progress from the postsynaptic side: signaling in synaptic differentiation.
Biederer T. Biederer T. Sci STKE. 2005 Mar 8;2005(274):pe9. doi: 10.1126/stke.2742005pe9. Sci STKE. 2005. PMID: 15755927 Review. - Molecular anatomy of the postsynaptic density.
Okabe S. Okabe S. Mol Cell Neurosci. 2007 Apr;34(4):503-18. doi: 10.1016/j.mcn.2007.01.006. Epub 2007 Jan 25. Mol Cell Neurosci. 2007. PMID: 17321751 Review. - SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.
Ko J, Kim S, Chung HS, Kim K, Han K, Kim H, Jun H, Kaang BK, Kim E. Ko J, et al. Neuron. 2006 Apr 20;50(2):233-45. doi: 10.1016/j.neuron.2006.04.005. Neuron. 2006. PMID: 16630835 - The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.
Nam J, Mah W, Kim E. Nam J, et al. Semin Cell Dev Biol. 2011 Jul;22(5):492-8. doi: 10.1016/j.semcdb.2011.06.005. Epub 2011 Jun 29. Semin Cell Dev Biol. 2011. PMID: 21736948 Review.
Cited by
- Neddylation is needed for synapse maturation.
Fu AK, Ip NY. Fu AK, et al. Nat Neurosci. 2015 Feb;18(2):164-6. doi: 10.1038/nn.3929. Nat Neurosci. 2015. PMID: 25622570 No abstract available. - Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.
Mah W, Ko J, Nam J, Han K, Chung WS, Kim E. Mah W, et al. J Neurosci. 2010 Apr 21;30(16):5559-68. doi: 10.1523/JNEUROSCI.4839-09.2010. J Neurosci. 2010. PMID: 20410109 Free PMC article. - Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions.
Han KA, Kim J, Kim H, Kim D, Lim D, Ko J, Um JW. Han KA, et al. Sci Rep. 2019 Nov 19;9(1):17094. doi: 10.1038/s41598-019-53519-1. Sci Rep. 2019. PMID: 31745231 Free PMC article. - Liraglutide Activates mTORC1 Signaling and AMPA Receptors in Rat Hippocampal Neurons Under Toxic Conditions.
Park SW, Mansur RB, Lee Y, Lee JH, Seo MK, Choi AJ, McIntyre RS, Lee JG. Park SW, et al. Front Neurosci. 2018 Oct 23;12:756. doi: 10.3389/fnins.2018.00756. eCollection 2018. Front Neurosci. 2018. PMID: 30405339 Free PMC article. - Intrinsic Morphologic and Physiologic Development of Human Derived Retinal Ganglion Cells In Vitro.
Risner ML, Pasini S, Chamling X, McGrady NR, Goldberg JL, Zack DJ, Calkins DJ. Risner ML, et al. Transl Vis Sci Technol. 2021 Aug 12;10(10):1. doi: 10.1167/tvst.10.10.1. Transl Vis Sci Technol. 2021. PMID: 34383881 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources