The regulation and function of Class III PI3Ks: novel roles for Vps34 - PubMed (original) (raw)
Review
. 2008 Feb 15;410(1):1-17.
doi: 10.1042/BJ20071427.
Affiliations
- PMID: 18215151
- DOI: 10.1042/BJ20071427
Review
The regulation and function of Class III PI3Ks: novel roles for Vps34
Jonathan M Backer. Biochem J. 2008.
Abstract
The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and is the sole PI3K in yeast. The homologue in mammalian cells, hVps34, has been studied extensively in the context of endocytic sorting. However, hVps34 also plays an important role in the ability of cells to respond to changes in nutrient conditions. Recent studies have shown that mammalian hVps34 is required for the activation of the mTOR (mammalian target of rapamycin)/S6K1 (S6 kinase 1) pathway, which regulates protein synthesis in response to nutrient availability. In both yeast and mammalian cells, Class III PI3Ks are also required for the induction of autophagy during nutrient deprivation. Finally, mammalian hVps34 is itself regulated by nutrients. Thus Class III PI3Ks are implicated in the regulation of both autophagy and, through the mTOR pathway, protein synthesis, and thus contribute to the integration of cellular responses to changing nutritional status.
Similar articles
- Regulation of class III (Vps34) PI3Ks.
Yan Y, Backer JM. Yan Y, et al. Biochem Soc Trans. 2007 Apr;35(Pt 2):239-41. doi: 10.1042/BST0350239. Biochem Soc Trans. 2007. PMID: 17371248 - pp60c-Src phosphorylates and activates vacuolar protein sorting 34 to mediate cellular transformation.
Hirsch DS, Shen Y, Dokmanovic M, Wu WJ. Hirsch DS, et al. Cancer Res. 2010 Jul 15;70(14):5974-83. doi: 10.1158/0008-5472.CAN-09-2682. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551057 - Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae.
Obara K, Noda T, Niimi K, Ohsumi Y. Obara K, et al. Genes Cells. 2008 Jun;13(6):537-47. doi: 10.1111/j.1365-2443.2008.01188.x. Genes Cells. 2008. PMID: 18533003 - The amino acid sensitive TOR pathway from yeast to mammals.
Dann SG, Thomas G. Dann SG, et al. FEBS Lett. 2006 May 22;580(12):2821-9. doi: 10.1016/j.febslet.2006.04.068. Epub 2006 May 2. FEBS Lett. 2006. PMID: 16684541 Review. - mVps34 is activated by an acute bout of resistance exercise.
Mackenzie MG, Hamilton DL, Murray JT, Baar K. Mackenzie MG, et al. Biochem Soc Trans. 2007 Nov;35(Pt 5):1314-6. doi: 10.1042/BST0351314. Biochem Soc Trans. 2007. PMID: 17956340 Review.
Cited by
- Aβ25-35-induced autophagy and apoptosis are prevented by the CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR signaling hub.
Ji Y, Ren J, Qian Y, Li J, Liu H, Yao Y, Sun J, Khanna R, Sun L. Ji Y, et al. PLoS One. 2024 Sep 26;19(9):e0309794. doi: 10.1371/journal.pone.0309794. eCollection 2024. PLoS One. 2024. PMID: 39325788 Free PMC article. - Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection.
Gong M, Peng C, Yang C, Wang Z, Qian H, Hu X, Zhou P, Shan C, Ding Q. Gong M, et al. PLoS Pathog. 2024 Aug 22;20(8):e1012444. doi: 10.1371/journal.ppat.1012444. eCollection 2024 Aug. PLoS Pathog. 2024. PMID: 39173055 Free PMC article. - The essential roles of lncRNAs/PI3K/AKT axis in gastrointestinal tumors.
Li P, Ma X, Gu X. Li P, et al. Front Cell Dev Biol. 2024 Aug 5;12:1442193. doi: 10.3389/fcell.2024.1442193. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39161590 Free PMC article. Review. - Targeting PI3K family with small-molecule inhibitors in cancer therapy: current clinical status and future directions.
Li H, Wen X, Ren Y, Fan Z, Zhang J, He G, Fu L. Li H, et al. Mol Cancer. 2024 Aug 10;23(1):164. doi: 10.1186/s12943-024-02072-1. Mol Cancer. 2024. PMID: 39127670 Free PMC article. Review. - The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk.
Rahmati S, Moeinafshar A, Rezaei N. Rahmati S, et al. J Transl Med. 2024 May 13;22(1):452. doi: 10.1186/s12967-024-05267-8. J Transl Med. 2024. PMID: 38741166 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous