Microbial influences in inflammatory bowel diseases - PubMed (original) (raw)
Review
Microbial influences in inflammatory bowel diseases
R Balfour Sartor. Gastroenterology. 2008 Feb.
Abstract
The predominantly anaerobic microbiota of the distal ileum and colon contain an extraordinarily complex variety of metabolically active bacteria and fungi that intimately interact with the host's epithelial cells and mucosal immune system. Crohn's disease, ulcerative colitis, and pouchitis are the result of continuous microbial antigenic stimulation of pathogenic immune responses as a consequence of host genetic defects in mucosal barrier function, innate bacterial killing, or immunoregulation. Altered microbial composition and function in inflammatory bowel diseases result in increased immune stimulation, epithelial dysfunction, or enhanced mucosal permeability. Although traditional pathogens probably are not responsible for these disorders, increased virulence of commensal bacterial species, particularly Escherichia coli, enhance their mucosal attachment, invasion, and intracellular persistence, thereby stimulating pathogenic immune responses. Host genetic polymorphisms most likely interact with functional bacterial changes to stimulate aggressive immune responses that lead to chronic tissue injury. Identification of these host and microbial alterations in individual patients should lead to selective targeted interventions that correct underlying abnormalities and induce sustained and predictable therapeutic responses.
Similar articles
- Bacteria in Crohn's disease: mechanisms of inflammation and therapeutic implications.
Balfour Sartor R. Balfour Sartor R. J Clin Gastroenterol. 2007 May-Jun;41 Suppl 1:S37-43. doi: 10.1097/MCG.0b013e31802db364. J Clin Gastroenterol. 2007. PMID: 17438417 Review. - Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases.
Packey CD, Sartor RB. Packey CD, et al. J Intern Med. 2008 Jun;263(6):597-606. doi: 10.1111/j.1365-2796.2008.01962.x. J Intern Med. 2008. PMID: 18479259 Review. - Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases.
Tlaskalová-Hogenová H, Stepánková R, Hudcovic T, Tucková L, Cukrowska B, Lodinová-Zádníková R, Kozáková H, Rossmann P, Bártová J, Sokol D, Funda DP, Borovská D, Reháková Z, Sinkora J, Hofman J, Drastich P, Kokesová A. Tlaskalová-Hogenová H, et al. Immunol Lett. 2004 May 15;93(2-3):97-108. doi: 10.1016/j.imlet.2004.02.005. Immunol Lett. 2004. PMID: 15158604 Review. - Etiology and pathogenesis of inflammatory bowel disease.
Schmidt C, Stallmach A. Schmidt C, et al. Minerva Gastroenterol Dietol. 2005 Jun;51(2):127-45. Minerva Gastroenterol Dietol. 2005. PMID: 15990703 Review.
Cited by
- Persimmon-derived tannin ameliorates the pathogenesis of ulcerative colitis in a murine model through inhibition of the inflammatory response and alteration of microbiota.
Kitabatake M, Matsumura Y, Ouji-Sageshima N, Nishioka T, Hara A, Kayano SI, Ito T. Kitabatake M, et al. Sci Rep. 2021 Mar 31;11(1):7286. doi: 10.1038/s41598-021-86608-1. Sci Rep. 2021. PMID: 33790314 Free PMC article. - Distinct Roles for CXCR6(+) and CXCR6(-) CD4(+) T Cells in the Pathogenesis of Chronic Colitis.
Mandai Y, Takahashi D, Hase K, Obata Y, Furusawa Y, Ebisawa M, Nakagawa T, Sato T, Katsuno T, Saito Y, Shimaoka T, Yokosuka O, Yokote K, Ohno H. Mandai Y, et al. PLoS One. 2013 Jun 19;8(6):e65488. doi: 10.1371/journal.pone.0065488. Print 2013. PLoS One. 2013. PMID: 23840334 Free PMC article. - Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease-An Overview.
Lopes SA, Roque-Borda CA, Duarte JL, Di Filippo LD, Borges Cardoso VM, Pavan FR, Chorilli M, Meneguin AB. Lopes SA, et al. Pharmaceutics. 2023 Nov 8;15(11):2600. doi: 10.3390/pharmaceutics15112600. Pharmaceutics. 2023. PMID: 38004578 Free PMC article. Review. - Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis.
Small CL, Reid-Yu SA, McPhee JB, Coombes BK. Small CL, et al. Nat Commun. 2013;4:1957. doi: 10.1038/ncomms2957. Nat Commun. 2013. PMID: 23748852 Free PMC article. - Regulation of intestinal microbiota by the NLR protein family.
Biswas A, Kobayashi KS. Biswas A, et al. Int Immunol. 2013 Apr;25(4):207-14. doi: 10.1093/intimm/dxs116. Epub 2013 Jan 15. Int Immunol. 2013. PMID: 23325116 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources