The effect of aminoguanidine on the blood-retinal barrier in streptozocin-induced diabetic rats - PubMed (original) (raw)
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- PMID: 1826545
The effect of aminoguanidine on the blood-retinal barrier in streptozocin-induced diabetic rats
H K Cho et al. Ophthalmic Surg. 1991 Jan.
Abstract
The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.
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