Adapting proteostasis for disease intervention - PubMed (original) (raw)
Review
. 2008 Feb 15;319(5865):916-9.
doi: 10.1126/science.1141448.
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- PMID: 18276881
- DOI: 10.1126/science.1141448
Review
Adapting proteostasis for disease intervention
William E Balch et al. Science. 2008.
Abstract
The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era.
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- R37 GM038109/GM/NIGMS NIH HHS/United States
- AG04342/AG/NIA NIH HHS/United States
- GM38109/GM/NIGMS NIH HHS/United States
- NS50636/NS/NINDS NIH HHS/United States
- DK46336/DK/NIDDK NIH HHS/United States
- AG026647/AG/NIA NIH HHS/United States
- AG 18917/AG/NIA NIH HHS/United States
- DK75295/DK/NIDDK NIH HHS/United States
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