The Men's Eating and Living (MEAL) study: a Cancer and Leukemia Group B pilot trial of dietary intervention for the treatment of prostate cancer - PubMed (original) (raw)
The Men's Eating and Living (MEAL) study: a Cancer and Leukemia Group B pilot trial of dietary intervention for the treatment of prostate cancer
J Kellogg Parsons et al. Urology. 2008 Sep.
Abstract
Objectives: To evaluate the feasibility of implementing a diet-based intervention in men with prostate cancer.
Methods: Seventy-four men aged 50 to 80 years with biopsy-proven adenocarcinoma of the prostate were randomized to receive either telephone-based dietary counseling or standardized, written nutritional information. Telephone dietary counseling targets included increased intakes of vegetables (particularly cruciferous vegetables and tomato products), whole grains, and beans/legumes. Dietary intakes and plasma carotenoid levels were assessed at baseline and at 6 months' follow-up.
Results: In the intervention arm, mean daily intakes of total vegetables, crucifers, tomato products, and beans/legumes increased by 76%, 143%, 292%, and 95%, respectively, whereas fat intake decreased by 12% (P = 0.02). In the control arm, there were no significant changes in mean intakes of total vegetables, tomato products, crucifers, beans/legumes, or fat. Similarly, in the intervention arm, mean plasma levels of alpha-carotene, beta-carotene, lutein, lycopene, and total carotenoids increased by 33%, 36%, 19%, 30%, and 26%, respectively (P <0.05). In the control arm, there were no significant changes in plasma levels of alpha- or beta-carotene, lutein, lycopene, or total carotenoids.
Conclusions: Telephone-based dietary counseling increases vegetable intake, decreases fat intake, and significantly increases plasma levels of potentially anticarcinogenic carotenoids in men with prostate cancer. These data support the feasibility of implementing clinical trials of dietary intervention in men with prostate cancer.
Similar articles
- Dietary modification in patients with prostate cancer on active surveillance: a randomized, multicentre feasibility study.
Parsons JK, Newman VA, Mohler JL, Pierce JP, Flatt S, Marshall J. Parsons JK, et al. BJU Int. 2008 May;101(10):1227-31. doi: 10.1111/j.1464-410X.2007.07365.x. Epub 2008 Jan 24. BJU Int. 2008. PMID: 18218061 Clinical Trial. - Telephone counseling promotes dietary change in healthy adults: results of a pilot trial.
Newman VA, Flatt SW, Pierce JP. Newman VA, et al. J Am Diet Assoc. 2008 Aug;108(8):1350-4. doi: 10.1016/j.jada.2008.05.007. J Am Diet Assoc. 2008. PMID: 18656575 - Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial.
Parsons JK, Zahrieh D, Mohler JL, Paskett E, Hansel DE, Kibel AS, Liu H, Seisler DK, Natarajan L, White M, Hahn O, Taylor J, Hartman SJ, Stroup SP, Van Veldhuizen P, Hall L, Small EJ, Morris MJ, Pierce JP, Marshall J. Parsons JK, et al. JAMA. 2020 Jan 14;323(2):140-148. doi: 10.1001/jama.2019.20207. JAMA. 2020. PMID: 31935026 Free PMC article. Clinical Trial. - Feasibility Outcomes of a Pilot Randomized Clinical Trial to Increase Cruciferous and Green Leafy Vegetable Intake in Posttreatment Head and Neck Cancer Survivors.
Crowder SL, Frugé AD, Douglas KG, Chen YT, Moody L, Delk-Licata A, Erdman JW Jr, Black M, Carroll WR, Spencer SA, Locher JL, Demark-Wahnefried W, Rogers LQ, Arthur AE. Crowder SL, et al. J Acad Nutr Diet. 2019 Apr;119(4):659-671. doi: 10.1016/j.jand.2018.11.005. Epub 2019 Jan 17. J Acad Nutr Diet. 2019. PMID: 30661935 Free PMC article. Clinical Trial. - Dietary intervention in the management of prostate cancer.
Demark-Wahnefried W, Moyad MA. Demark-Wahnefried W, et al. Curr Opin Urol. 2007 May;17(3):168-74. doi: 10.1097/MOU.0b013e3280eb10fc. Curr Opin Urol. 2007. PMID: 17414514 Free PMC article. Review.
Cited by
- Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation.
Magbanua MJ, Roy R, Sosa EV, Weinberg V, Federman S, Mattie MD, Hughes-Fulford M, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM. Magbanua MJ, et al. PLoS One. 2011;6(9):e24004. doi: 10.1371/journal.pone.0024004. Epub 2011 Sep 1. PLoS One. 2011. PMID: 21912659 Free PMC article. Clinical Trial. - A randomized pilot trial of dietary modification for the chemoprevention of noninvasive bladder cancer: the dietary intervention in bladder cancer study.
Parsons JK, Pierce JP, Natarajan L, Newman VA, Barbier L, Mohler J, Rock CL, Heath DD, Guru K, Jameson MB, Li H, Mirheydar H, Holmes MA, Marshall J. Parsons JK, et al. Cancer Prev Res (Phila). 2013 Sep;6(9):971-8. doi: 10.1158/1940-6207.CAPR-13-0050. Epub 2013 Jul 18. Cancer Prev Res (Phila). 2013. PMID: 23867158 Free PMC article. Clinical Trial. - Assessing the nutritional needs of men with prostate cancer.
McLaughlin K, Hedden L, Pollock P, Higano C, Murphy RA. McLaughlin K, et al. Nutr J. 2019 Dec 2;18(1):81. doi: 10.1186/s12937-019-0506-7. Nutr J. 2019. PMID: 31791348 Free PMC article. - Long-term outcomes of the FRESH START trial: exploring the role of self-efficacy in cancer survivors' maintenance of dietary practices and physical activity.
Mosher CE, Lipkus I, Sloane R, Snyder DC, Lobach DF, Demark-Wahnefried W. Mosher CE, et al. Psychooncology. 2013 Apr;22(4):876-85. doi: 10.1002/pon.3089. Epub 2012 Apr 30. Psychooncology. 2013. PMID: 22544562 Free PMC article. Clinical Trial. - A randomized trial of diet in men with early stage prostate cancer on active surveillance: rationale and design of the Men's Eating and Living (MEAL) Study (CALGB 70807 [Alliance]).
Parsons JK, Pierce JP, Mohler J, Paskett E, Jung SH, Humphrey P, Taylor JR, Newman VA, Barbier L, Rock CL, Marshall J. Parsons JK, et al. Contemp Clin Trials. 2014 Jul;38(2):198-203. doi: 10.1016/j.cct.2014.05.002. Epub 2014 May 13. Contemp Clin Trials. 2014. PMID: 24837543 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical