Estrus cycle stage modifies the presentation of stress-induced startle suppression in female Sprague-Dawley rats - PubMed (original) (raw)
. 2008 Mar 18;93(4-5):1019-23.
doi: 10.1016/j.physbeh.2008.01.012. Epub 2008 Jan 17.
Affiliations
- PMID: 18281068
- DOI: 10.1016/j.physbeh.2008.01.012
Estrus cycle stage modifies the presentation of stress-induced startle suppression in female Sprague-Dawley rats
Kevin D Beck et al. Physiol Behav. 2008.
Abstract
Tailshock stress causes transient reductions in startle reactivity, associative learning and open field activity in female rats in an ovarian hormone dependent manner. Others have shown estrogen modulation of associative learning by testing across the estrus cycle and pharmacological manipulations. Here we tested whether stress-induced suppression of startle reactivity can be attributed to circulating ovarian hormones. Female rats were tracked across the estrus cycle and subjected to the stressor (2 h periodic tailshock) the morning of diestrus, proestrus, estrus, or metestrus. Startle reactivity was tested 2 h following the cessation of the tailshock. Using a multi-stimulus protocol, we determined there were differences in startle sensitivity and responsivity. Following stressor exposure, estrus females exhibited reduced startle responsivity. In contrast, diestrus females exhibited increased sensitivity to the lowest acoustic stimulus. The results are discussed with respect to ovarian hormone regulation of the immune system and sensory reactivity during and following trauma that may lead to different abnormal behaviors in females in the wake of traumatic stress.
Similar articles
- Stress-induced reductions of sensory reactivity in female rats depend on ovarian hormones and the application of a painful stressor.
Beck KD, Servatius RJ. Beck KD, et al. Horm Behav. 2005 May;47(5):532-9. doi: 10.1016/j.yhbeh.2004.12.011. Horm Behav. 2005. PMID: 15811354 - Effects of sex and estrous cycle on modulation of the acoustic startle response in mice.
Plappert CF, Rodenbücher AM, Pilz PK. Plappert CF, et al. Physiol Behav. 2005 Mar 31;84(4):585-94. doi: 10.1016/j.physbeh.2005.02.004. Physiol Behav. 2005. PMID: 15811394 - Interleukin-1beta as a mechanism for stress-induced startle suppression in females.
Beck KD, Servatius RJ. Beck KD, et al. Ann N Y Acad Sci. 2006 Jul;1071:534-7. doi: 10.1196/annals.1364.058. Ann N Y Acad Sci. 2006. PMID: 16891613 - A stress-induced anxious state in male rats: corticotropin-releasing hormone induces persistent changes in associative learning and startle reactivity.
Servatius RJ, Beck KD, Moldow RL, Salameh G, Tumminello TP, Short KR. Servatius RJ, et al. Biol Psychiatry. 2005 Apr 15;57(8):865-72. doi: 10.1016/j.biopsych.2005.01.015. Biol Psychiatry. 2005. PMID: 15820707 - Top-down modulation of prepulse inhibition of the startle reflex in humans and rats.
Li L, Du Y, Li N, Wu X, Wu Y. Li L, et al. Neurosci Biobehav Rev. 2009 Sep;33(8):1157-67. doi: 10.1016/j.neubiorev.2009.02.001. Epub 2009 Feb 11. Neurosci Biobehav Rev. 2009. PMID: 19747594 Review.
Cited by
- Fear-conditioning to unpredictable threats reveals sex differences in rat fear-potentiated startle (FPS).
Olivera-Pasilio V, Dabrowska J. Olivera-Pasilio V, et al. bioRxiv [Preprint]. 2023 Mar 8:2023.03.06.531430. doi: 10.1101/2023.03.06.531430. bioRxiv. 2023. PMID: 36945466 Free PMC article. Updated. Preprint. - Western High-Fat Diet Consumption during Adolescence Increases Susceptibility to Traumatic Stress while Selectively Disrupting Hippocampal and Ventricular Volumes.
Kalyan-Masih P, Vega-Torres JD, Miles C, Haddad E, Rainsbury S, Baghchechi M, Obenaus A, Figueroa JD. Kalyan-Masih P, et al. eNeuro. 2016 Nov 8;3(5):ENEURO.0125-16.2016. doi: 10.1523/ENEURO.0125-16.2016. eCollection 2016 Sep-Oct. eNeuro. 2016. PMID: 27844058 Free PMC article. - Fear-Conditioning to Unpredictable Threats Reveals Sex and Strain Differences in Rat Fear-Potentiated Startle (FPS).
Olivera-Pasilio V, Dabrowska J. Olivera-Pasilio V, et al. Neuroscience. 2023 Oct 15;530:108-132. doi: 10.1016/j.neuroscience.2023.08.030. Epub 2023 Aug 26. Neuroscience. 2023. PMID: 37640137 Free PMC article. - Sex differences in traumatic stress reactivity in rats with and without a history of alcohol drinking.
Albrechet-Souza L, Schratz CL, Gilpin NW. Albrechet-Souza L, et al. Biol Sex Differ. 2020 May 11;11(1):27. doi: 10.1186/s13293-020-00303-w. Biol Sex Differ. 2020. PMID: 32393336 Free PMC article. - Sex differences in learning processes of classical and operant conditioning.
Dalla C, Shors TJ. Dalla C, et al. Physiol Behav. 2009 May 25;97(2):229-38. doi: 10.1016/j.physbeh.2009.02.035. Epub 2009 Mar 9. Physiol Behav. 2009. PMID: 19272397 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical