A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost - PubMed (original) (raw)

doi: 10.1215/15228517-2007-053. Epub 2008 Feb 20.

Michael R Zalutsky, Gamal Akabani, R Edward Coleman, Allan H Friedman, James E Herndon 2nd, Roger E McLendon, Charles N Pegram, Jennifer A Quinn, Jeremy N Rich, James J Vredenburgh, Annick Desjardins, Sridharan Guruangan, Susan Boulton, Renee H Raynor, Jeanette M Dowell, Terence Z Wong, Xiao-Guang Zhao, Henry S Friedman, Darell D Bigner

Affiliations

A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost

David A Reardon et al. Neuro Oncol. 2008 Apr.

Abstract

The purpose of this study was to determine the feasibility and assess the efficacy and toxicity, among newly diagnosed malignant glioma patients, of administering (131)I-labeled murine antitenascin monoclonal antibody 81C6 ((131)I-81C6) into a surgically created resection cavity (SCRC) to achieve a patient-specific, 44-Gy boost to the 2-cm SCRC margin. A radioactivity dose of (131)I-81C6 calculated to achieve a 44-Gy boost to the SCRC was administered, followed by conventional external beam radiotherapy (XRT) and chemotherapy. Twenty-one patients were enrolled in the study: 16 with glioblastoma multiforme (GBM) and 5 with anaplastic astrocytoma. Twenty patients received the targeted 44-Gy boost (+/-10%) to the SCRC. Attributable toxicity was mild and limited to reversible grade 3 neutropenia or thrombocytopenia (n = 3; 14%), CNS wound infections (n = 3; 14%), and headache (n = 2; 10%). With a median follow-up of 151 weeks, median overall survival times for all patients and those with GBM are 96.6 and 90.6 weeks, respectively; 87% of GBM patients are alive at 1 year. It is feasible to consistently achieve a 44-Gy boost dose to the SCRC margin with patient-specific dosing of (131)I-81C6. Our study regimen ((131)I-81C6 + XRT + temozolomide) was well tolerated and had encouraging survival. To determine if selection of good-prognosis patients affects outcome associated with this approach, the U.S. Food and Drug Administration has approved a trial randomizing newly diagnosed GBM patients to either our study regimen or standard XRT plus temozolomide.

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Figures

Fig. 1

Fig. 1

Kaplan-Meier overall survival estimates for all patients following stratification by histology.

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