DDE, a degradation product of DDT, and duration of lactation in a highly exposed area of Mexico - PubMed (original) (raw)

DDE, a degradation product of DDT, and duration of lactation in a highly exposed area of Mexico

Lea A Cupul-Uicab et al. Environ Health Perspect. 2008 Feb.

Abstract

Background: Higher levels of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), the major degradation product of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), have been related to shorter duration of breast-feeding in previous studies. If DDE truly shortens lactation, this has public health importance regarding infant mortality and the use of DDT for malaria control.

Objective: Our aim was to assess the relationship of maternal DDE concentrations with length of subsequent lactation.

Methods: We conducted a relatively large study in a highly exposed area of Mexico. We followed 784 mother-son pairs to determine length of lactation. DDE and DDT were measured in maternal serum obtained within a day of delivery. We fit proportional hazard models with and without stratifying by previous breast-feeding, because an association of DDE with duration of lactation among those who breast-fed previously could be attributed to a noncausal mechanism.

Results: Compared with those with DDE concentrations < or = 3.00 microg/g, the adjusted hazard ratios of weaning according to DDE category were, for concentrations 3.01-6.00 microg/g, 1.27 [95% confidence interval (CI), 1.04-1.55]; for concentrations 6.01-9.00 microg/g, 1.23 (95% CI, 0.92-1.63); and for concentrations > 9.00 microg/g, 1.17 (95% CI, 0.92-1.49). The corresponding ratios for women who previously breast-fed were 1.40 (95% CI, 1.06-1.87); 1.91 (95% CI, 1.24-2.93); and 1.76 (95% CI, 1.22-2.53). Those for women who had not breast-fed previously were 1.14 (95% CI, 0.86-1.52); 0.90 (95% CI, 0.61-1.31); and 0.91 (95% CI, 0.66-1.26).

Conclusions: Data from our relatively large study in a highly exposed area of Mexico did not support the hypothesis that exposure to DDE shortens length of lactation. The association seen in women who previously breast-fed was likely attributed to a noncausal mechanism. Nonetheless, whether DDT has other important adverse effects on humans is still an open question.

Keywords: DDE; DDT; breast-feeding; infant; lactation.

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Figures

Figure 1

Figure 1

Kaplan-Meier survival curves by DDE concentration categories (μg/g lipids) in women with (n = 416) (A) and without (n = 368) (B) history of previous lactation. The graph was truncated at 25 months.

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References

    1. [Anonymous] Suppressing lactation. Br Med J. 1977;1(6055):189. - PMC - PubMed
    1. Capurro H, Konichezky S, Fonseca D, Caldeyro-Barcia R. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr. 1978;93(1):120–122. - PubMed
    1. Chen A, Rogan WJ. Nonmalarial infant deaths and DDT use for malaria control. Emerg Infect Dis. 2003;9(8):960–964. - PMC - PubMed
    1. Curtis CF. Should the use of DDT be revived for malaria vector control? Biomedica. 2002;22(4):455–461. - PubMed
    1. Gartner LM, Morton J, Lawrence RA, Naylor AJ, O’Hare D, Schanler RJ, et al. Breastfeeding and the use of human milk. Pediatrics. 2005;115(2):496–506. - PubMed

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