LPS/TLR4 signal transduction pathway - PubMed (original) (raw)

Review

. 2008 May;42(2):145-151.

doi: 10.1016/j.cyto.2008.01.006. Epub 2008 Mar 4.

Affiliations

• PMID: 18304834
• DOI: 10.1016/j.cyto.2008.01.006

Review

LPS/TLR4 signal transduction pathway

Yong-Chen Lu et al. Cytokine. 2008 May.

Abstract

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.

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