Impact of new-onset diabetes mellitus on development of atrial fibrillation and heart failure in high-risk hypertension (from the VALUE Trial) - PubMed (original) (raw)
Impact of new-onset diabetes mellitus on development of atrial fibrillation and heart failure in high-risk hypertension (from the VALUE Trial)
Tonje Amb Aksnes et al. Am J Cardiol. 2008.
Abstract
Hypertension and diabetes mellitus (DM) are known risk factors for atrial fibrillation (AF). We investigated the influence of new-onset DM on developing AF in the VALUE trial population of high-risk hypertensive patients. Five thousand two hundred fifty patients of the 15,245 participants in the VALUE trial had DM at baseline and 1,298 of the initially nondiabetic patients developed DM during the average 4.2-year follow-up. The presence of AF was determined by central analyzed electrocardiograms at baseline and changes were assessed yearly. Patients without AF at baseline and with any AF by later electrocardiograms were defined as patients with new-onset AF. Patients with new-onset and baseline DM were compared with patients without DM by a Cox regression model with adjustment for prespecified covariates. Five hundred fifty-one patients developed new-onset AF during the trial. Patients with new-onset DM had a significantly higher event rate of new-onset AF with a hazard ratio of 1.49 (1.14 to 1.94, p = 0.0031) compared with patients without DM, and there was a trend toward more AF in patients with DM at baseline. Patients with new-onset DM had also more persistent AF (hazard ratio 1.87, 1.28 to 2.74, p = 0.0014). Patients with new-onset DM and AF had a hazard ratio of 3.56 for heart failure (2.86 to 4.44, p <0.0001) compared with patients with new-onset DM without AF. In conclusion, hypertensive patients who developed DM during the VALUE trial had more AF than did patients without DM, and this may explain some of their concomitant high risk of hospitalization for heart failure.
Comment in
- Inflammation: another potential mechanism between diabetes mellitus and atrial fibrillation.
Liu T, Li G. Liu T, et al. Am J Cardiol. 2008 Jun 1;101(11):1681-2. doi: 10.1016/j.amjcard.2008.04.006. Am J Cardiol. 2008. PMID: 18489956 No abstract available.
Similar articles
- Atrial fibrillation at baseline and during follow-up in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).
Haywood LJ, Ford CE, Crow RS, Davis BR, Massie BM, Einhorn PT, Williard A; ALLHAT Collaborative Research Group. Haywood LJ, et al. J Am Coll Cardiol. 2009 Nov 24;54(22):2023-31. doi: 10.1016/j.jacc.2009.08.020. J Am Coll Cardiol. 2009. PMID: 19926008 Clinical Trial. - Prognostic impact of types of atrial fibrillation in acute coronary syndromes.
Lau DH, Huynh LT, Chew DP, Astley CM, Soman A, Sanders P. Lau DH, et al. Am J Cardiol. 2009 Nov 15;104(10):1317-23. doi: 10.1016/j.amjcard.2009.06.055. Epub 2009 Sep 25. Am J Cardiol. 2009. PMID: 19892044 - Incidence of atrial fibrillation in relation to changing heart rate over time in hypertensive patients: the LIFE study.
Okin PM, Wachtell K, Kjeldsen SE, Julius S, Lindholm LH, Dahlöf B, Hille DA, Nieminen MS, Edelman JM, Devereux RB. Okin PM, et al. Circ Arrhythm Electrophysiol. 2008 Dec;1(5):337-43. doi: 10.1161/CIRCEP.108.795351. Epub 2008 Dec 2. Circ Arrhythm Electrophysiol. 2008. PMID: 19808428 Clinical Trial. - The complex interplay between diabetes mellitus and atrial fibrillation.
Yildiz M, Lavie CJ, Morin DP, Oktay AA. Yildiz M, et al. Expert Rev Cardiovasc Ther. 2022 Sep;20(9):707-717. doi: 10.1080/14779072.2022.2115357. Epub 2022 Aug 25. Expert Rev Cardiovasc Ther. 2022. PMID: 35984314 Review. - [Diabetes mellitus and atrial fibrillation: evidence of a pathophysiological, clinical and epidemiological association beyond the thromboembolic risk].
Proietti R, Russo V, Wu MA, Maggioni AP, Marfella R. Proietti R, et al. G Ital Cardiol (Rome). 2017 Mar;18(3):199-207. doi: 10.1714/2674.27397. G Ital Cardiol (Rome). 2017. PMID: 28398378 Review. Italian.
Cited by
- Diabetes mellitus is an independent risk factor for atrial fibrillation in a general Chinese population.
Sun G, Ma M, Ye N, Wang J, Chen Y, Dai D, Sun Y. Sun G, et al. J Diabetes Investig. 2016 Sep;7(5):791-6. doi: 10.1111/jdi.12476. Epub 2016 Feb 21. J Diabetes Investig. 2016. PMID: 27180678 Free PMC article. - Presence of diabetic microvascular complications does not incrementally increase risk of ischemic stroke in diabetic patients with atrial fibrillation: A nationwide cohort study.
Chou AY, Liu CJ, Chao TF, Wang KL, Tuan TC, Chen TJ, Chen SA. Chou AY, et al. Medicine (Baltimore). 2016 Jul;95(27):e3992. doi: 10.1097/MD.0000000000003992. Medicine (Baltimore). 2016. PMID: 27399075 Free PMC article. - Risk assessment for incident heart failure in individuals with atrial fibrillation.
Schnabel RB, Rienstra M, Sullivan LM, Sun JX, Moser CB, Levy D, Pencina MJ, Fontes JD, Magnani JW, McManus DD, Lubitz SA, Tadros TM, Wang TJ, Ellinor PT, Vasan RS, Benjamin EJ. Schnabel RB, et al. Eur J Heart Fail. 2013 Aug;15(8):843-9. doi: 10.1093/eurjhf/hft041. Epub 2013 Apr 17. Eur J Heart Fail. 2013. PMID: 23594831 Free PMC article. - Blood pressure control in patients with comorbidities.
Schmieder RE, Ruilope LM. Schmieder RE, et al. J Clin Hypertens (Greenwich). 2008 Aug;10(8):624-31. doi: 10.1111/j.1751-7176.2008.08172.x. J Clin Hypertens (Greenwich). 2008. PMID: 18772645 Free PMC article. Review. - Life's Simple 7 Approach to Atrial Fibrillation Prevention.
Isakadze N, B P, B S, Patel R, Baer J, Isiadinso I, Alonso A, Lloyd M, Sperling L. Isakadze N, et al. J Atr Fibrillation. 2018 Oct 31;11(3):2051. doi: 10.4022/jafib.2051. eCollection 2018 Oct-Nov. J Atr Fibrillation. 2018. PMID: 31139271 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical