Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches - PubMed (original) (raw)

doi: 10.1038/ni1571. Epub 2008 Mar 2.

Affiliations

• PMID: 18311142
• DOI: 10.1038/ni1571

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches

Anita Sapoznikov et al. Nat Immunol. 2008 Apr.

Abstract

Beyond its established function in hematopoiesis, the bone marrow hosts mature lymphocytes and acts as a secondary lymphoid organ in the initiation of T cell and B cell responses. Here we report the characterization of bone marrow-resident dendritic cells (bmDCs). Multiphoton imaging showed that bmDCs were organized into perivascular clusters that enveloped blood vessels and were seeded with mature B lymphocytes and T lymphocytes. Conditional ablation of bmDCs in these bone marrow immune niches led to the specific loss of mature B cells, a phenotype that could be reversed by overexpression of the antiapoptotic factor Bcl-2 in B cells. The presence of bmDCs promoted the survival of recirculating B cells in the bone marrow through the production of macrophage migration-inhibitory factor. Thus, bmDCs are critical for the maintenance of recirculating B cells in the bone marrow.

PubMed Disclaimer

Comment in

• New niches for B cells.
  Nagasawa T. Nagasawa T. Nat Immunol. 2008 Apr;9(4):345-6. doi: 10.1038/ni0408-345. Nat Immunol. 2008. PMID: 18349811 No abstract available.

Similar articles

• The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development.
  Hess J, Nielsen PJ, Fischer KD, Bujard H, Wirth T. Hess J, et al. Mol Cell Biol. 2001 Mar;21(5):1531-9. doi: 10.1128/MCB.21.5.1531-1539.2001. Mol Cell Biol. 2001. PMID: 11238890 Free PMC article.
• Effect of a bcl-2 transgene on production and localization of precursor B cells in mouse bone marrow.
  Janani R, Harris AW, Strasser A, Dhanoa S, Plyam R, Osmond DG. Janani R, et al. Exp Hematol. 1998 Sep;26(10):982-90. Exp Hematol. 1998. PMID: 9728934
• Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes.
  Cariappa A, Mazo IB, Chase C, Shi HN, Liu H, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U, Pillai S. Cariappa A, et al. Immunity. 2005 Oct;23(4):397-407. doi: 10.1016/j.immuni.2005.09.004. Immunity. 2005. PMID: 16226505
• Bone marrow B cell development.
  Vogler LB. Vogler LB. Clin Haematol. 1982 Oct;11(3):509-29. Clin Haematol. 1982. PMID: 6756732 Review. No abstract available.
• Microenvironmental niches in the bone marrow required for B-cell development.
  Nagasawa T. Nagasawa T. Nat Rev Immunol. 2006 Feb;6(2):107-16. doi: 10.1038/nri1780. Nat Rev Immunol. 2006. PMID: 16491135 Review.

Cited by

• Mouse dendritic cells in the steady state: Hypoxia, autophagy, and stem cell factor.
  Barroeta Seijas AB, Simonetti S, Filippi I, Naldini A, Favaretto G, Colombo T, Natalini A, Antonangeli F, Laffranchi M, Sozzani S, Santoni A, Di Rosa F. Barroeta Seijas AB, et al. Cell Biochem Funct. 2022 Oct;40(7):718-728. doi: 10.1002/cbf.3737. Epub 2022 Sep 7. Cell Biochem Funct. 2022. PMID: 36069062 Free PMC article.
• Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.
  Goedhart M, Slot E, Pascutti MF, Geerman S, Rademakers T, Nota B, Huveneers S, Buul JDV, MacNamara KC, Voermans C, Nolte MA. Goedhart M, et al. Cells. 2021 Dec 24;11(1):55. doi: 10.3390/cells11010055. Cells. 2021. PMID: 35011617 Free PMC article.
• The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
  Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B. Schneppenheim J, et al. Mol Cell Biol. 2014 Apr;34(8):1398-411. doi: 10.1128/MCB.00038-14. Epub 2014 Feb 3. Mol Cell Biol. 2014. PMID: 24492962 Free PMC article.
• A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.
  Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang XR, Lan HY, Lolis E, Nikolic-Paterson D, Bucala R. Leng L, et al. J Immunol. 2011 Jan 1;186(1):527-38. doi: 10.4049/jimmunol.1001767. Epub 2010 Nov 24. J Immunol. 2011. PMID: 21106847 Free PMC article.
• The elusive nature and function of mesenchymal stem cells.
  Nombela-Arrieta C, Ritz J, Silberstein LE. Nombela-Arrieta C, et al. Nat Rev Mol Cell Biol. 2011 Feb;12(2):126-31. doi: 10.1038/nrm3049. Nat Rev Mol Cell Biol. 2011. PMID: 21253000 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • H1 Connect - Access expert opinions and insights on biomedical research.
  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)