Polyadenylation in mammalian mitochondria: insights from recent studies - PubMed (original) (raw)

Review

. 2008 Apr;1779(4):266-9.

doi: 10.1016/j.bbagrm.2008.02.001. Epub 2008 Feb 14.

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Review

Polyadenylation in mammalian mitochondria: insights from recent studies

Takashi Nagaike et al. Biochim Biophys Acta. 2008 Apr.

Abstract

Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3' termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.

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