Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma - PubMed (original) (raw)
doi: 10.1111/j.1365-2141.2008.07077.x. Epub 2008 Mar 3.
Shira Gal, Heather M Dunlop, Beena Pushkaran, Amanda P Liggins, Karen Pulford, Alison H Banham, Francesco Pezzella, Jacqueline Boultwood, James S Wainscoat, Christian S R Hatton, Adrian L Harris
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- PMID: 18318758
- DOI: 10.1111/j.1365-2141.2008.07077.x
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Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
Charles H Lawrie et al. Br J Haematol. 2008 May.
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Abstract
Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0.05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers.
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