Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways - PubMed (original) (raw)

. 2008 May;123(4):359-69.

doi: 10.1007/s00439-008-0485-9. Epub 2008 Mar 5.

Xin Liu, Karen Mestan, Yunxian Yu, Shanchun Zhang, Yaping Fang, Colleen Pearson, Katherin Ortiz, Barry Zuckerman, Howard Bauchner, Sandra Cerda, Phillip G Stubblefield, Xiping Xu, Xiaobin Wang

Affiliations

Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways

Hui-Ju Tsai et al. Hum Genet. 2008 May.

Abstract

Preterm delivery (PTD, <37 weeks of gestation) is a significant clinical and public health problem. Previously, we reported that maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 synergistically increase the risk of low birth weight. This study investigates the relationship between maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 with preterm delivery (PTD) as a whole and preterm subgroups. This case-control study included 1,749 multi-ethnic mothers (571 with PTD and 1,178 controls) enrolled at Boston Medical Center. After adjusting covariates, regression analyses were performed to identify individual and joint associations of maternal smoking, two functional variants of CYP1A1 and GSTT1 with PTD. We observed a moderate effect of maternal smoking on PTD (OR = 1.6; 95% CI: 1.1-2.2). We found that compared to non-smoking mothers with low-risk genotypes, there was a significant joint association of maternal smoking, CYP1A1 (Aa/aa) and GSTT1 (absent) genotypes with gestational age (beta = -3.37; SE = 0.86; P = 9 x 10(-5)) and with PTD (OR = 5.8; 95% CI: 2.0-21.1), respectively. Such joint association was particularly strong in certain preterm subgroups, including spontaneous PTD (OR = 8.3; 95% CI: 2.7-30.6), PTD < 32 weeks (OR = 11.1; 95% CI: 2.9-47.7), and PTD accompanied by histologic chorioamnionitis (OR = 15.6; 95% CI: 4.1-76.7). Similar patterns were observed across ethnic groups. Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes. Such joint associations were strongest among PTD accompanied by histologic chorioamnionitis.

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Fig. 1

Joint association of maternal smoking during pregnancy, CYP1A1 and GSTT1 polymorphisms with PTD and preterm subgroups

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References

    1. Anonymous press Tna. Preterm birth: cause, consequences, and prevention. Institute of medicine of the national academies (Committee on understanding premature birth and assuring healthy outcomes board on health sciences policy); Washington DC: 2006a.
    1. Anonymous Preterm birth: crisis and opportunity. Lancet. 2006b;368:339. - PubMed
    1. Bartsch H. DNA adducts in human carcinogenesis: etiological relevance and structure–activity relationship. Mutat Res. 1996;340:67–79. - PubMed
    1. Bartsch H, Rojas M, Alexandrov K, Camus AM, Castegnaro M, Malaveille C, Anttila S, Hirvonen K, Husgafvel-Pursiainen K, Hietanen E, et al. Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans. Pharmacogenetics. 1995;5 (Spec):S84–S90. - PubMed
    1. Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann Stat. 2001;29:1165–1188.

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