Hepatocyte growth factor promotes migration of human myeloma cells - PubMed (original) (raw)

doi: 10.3324/haematol.11867. Epub 2008 Mar 6.

Affiliations

• PMID: 18326526
• DOI: 10.3324/haematol.11867

Free article

Hepatocyte growth factor promotes migration of human myeloma cells

Randi Utne Holt et al. Haematologica. 2008 Apr.

Free article

Abstract

Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events. We studied migration in a Transwell two-chamber assay and tested the motogenic effect of various cytokines. In addition to insulin-like growth factor-1 and stromal cell-derived growth factor-1alpha, previously known as chemoattractants for myeloma cells, we identified hepatocyte growth factor as a potent attractant for myeloma cells. Hepatocyte growth factor-mediated migration was dependent on phosphatidylinositol-3-kinase, involved the MAPK/Erk signaling cascade and VLA-4 integrins, but did not involve Akt, mTOR or G proteins.

PubMed Disclaimer

Similar articles

• Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor.
  Holt RU, Baykov V, Rø TB, Brabrand S, Waage A, Sundan A, Børset M. Holt RU, et al. Haematologica. 2005 Apr;90(4):479-88. Haematologica. 2005. PMID: 15820943
• Mn2+ regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF-1alpha.
  Slørdahl TS, Hov H, Holt RU, Baykov V, Syversen T, Sundan A, Waage A, Børset M. Slørdahl TS, et al. Eur J Haematol. 2008 Dec;81(6):437-47. doi: 10.1111/j.1600-0609.2008.01148.x. Epub 2008 Sep 4. Eur J Haematol. 2008. PMID: 18774952
• A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells.
  Hov H, Holt RU, Rø TB, Fagerli UM, Hjorth-Hansen H, Baykov V, Christensen JG, Waage A, Sundan A, Børset M. Hov H, et al. Clin Cancer Res. 2004 Oct 1;10(19):6686-94. doi: 10.1158/1078-0432.CCR-04-0874. Clin Cancer Res. 2004. PMID: 15475459
• Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4.
  Matsumoto K, Nakamura T, Sakai K, Nakamura T. Matsumoto K, et al. Proteomics. 2008 Aug;8(16):3360-70. doi: 10.1002/pmic.200800156. Proteomics. 2008. PMID: 18646008 Review.
• The malignant clone and the bone-marrow environment.
  Podar K, Richardson PG, Hideshima T, Chauhan D, Anderson KC. Podar K, et al. Best Pract Res Clin Haematol. 2007 Dec;20(4):597-612. doi: 10.1016/j.beha.2007.08.002. Best Pract Res Clin Haematol. 2007. PMID: 18070708 Review.

Cited by

• Cimigenol depresses acute myeloid leukemia cells protected by breaking bone marrow stromal cells via CXCR4/SDF‑1α.
  Ma B, Dai H, Dai X, Qian S, Sha X, Sun X. Ma B, et al. Exp Ther Med. 2022 Dec 30;25(2):80. doi: 10.3892/etm.2022.11779. eCollection 2023 Feb. Exp Ther Med. 2022. PMID: 36684661 Free PMC article.
• Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization.
  Purushothaman A, Toole BP. Purushothaman A, et al. J Biol Chem. 2014 Feb 28;289(9):5499-509. doi: 10.1074/jbc.M113.532143. Epub 2014 Jan 8. J Biol Chem. 2014. PMID: 24403068 Free PMC article.
• Lack of correlation between angiogenic cytokines and serum insulin-like growth factor-1 in patients with multiple myeloma.
  Pappa CA, Tsirakis G, Psarakis FE, Kolovou A, Tsigaridaki M, Stafylaki D, Sfiridaki K, Alexandrakis MG. Pappa CA, et al. Med Oncol. 2013 Mar;30(1):363. doi: 10.1007/s12032-012-0363-0. Epub 2012 Dec 25. Med Oncol. 2013. PMID: 23266941
• Allelic mutations in noncoding genomic sequences construct novel transcription factor binding sites that promote gene overexpression.
  Tian E, Børset M, Sawyer JR, Brede G, Våtsveen TK, Hov H, Waage A, Barlogie B, Shaughnessy JD Jr, Epstein J, Sundan A. Tian E, et al. Genes Chromosomes Cancer. 2015 Nov;54(11):692-701. doi: 10.1002/gcc.22280. Epub 2015 Jul 29. Genes Chromosomes Cancer. 2015. PMID: 26220195 Free PMC article.
• Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Purushothaman A, Chen L, Yang Y, Sanderson RD. Purushothaman A, et al. J Biol Chem. 2008 Nov 21;283(47):32628-36. doi: 10.1074/jbc.M806266200. Epub 2008 Sep 23. J Biol Chem. 2008. PMID: 18812315 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Pagepress Publications

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal