Role of AMP-activated protein kinase in autophagy and proteasome function - PubMed (original) (raw)

. 2008 May 9;369(3):964-8.

doi: 10.1016/j.bbrc.2008.02.126. Epub 2008 Mar 6.

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• PMID: 18328803
• DOI: 10.1016/j.bbrc.2008.02.126

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Role of AMP-activated protein kinase in autophagy and proteasome function

Rosa Viana et al. Biochem Biophys Res Commun. 2008.

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Abstract

In this work, we have examined the possible role of AMP-activated protein kinase (a key energy sensor) in regulating intracellular protein degradation. We have found that AICAR, a known activator of AMPK, has a dual effect. On one hand, it inhibits autophagy by a mechanism independent of AMPK activity; AICAR decreases class III PI3-kinase binding to beclin-1 and this effect counteracts and reverses the known positive effect of AMPK activity on autophagy. On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand.

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