Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele - PubMed (original) (raw)

doi: 10.1159/000119730. Epub 2008 Mar 7.

Anna Poleggi, Maria Puopolo, Maurizio Pocchiari, Piero Antuono, Gloria Dal Forno, David R Wekstein, Maria G Matera, Davide Seripa, Adele Acciarri, Alessandra Bizzarro, Alessandra Lauria, Carlo Masullo

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• PMID: 18332630
• DOI: 10.1159/000119730

Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele

Claudia Giannattasio et al. Dement Geriatr Cogn Disord. 2008.

Abstract

We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival. When this subgroup of patients was stratified by sex, the effect of APOE was observed in women, but not in men.

(c) 2008 S. Karger AG, Basel.

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