Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom? - PubMed (original) (raw)

. 2008 Jun 26;190(1):74-84.

doi: 10.1016/j.bbr.2008.02.005. Epub 2008 Feb 8.

Affiliations

• PMID: 18342378
• DOI: 10.1016/j.bbr.2008.02.005

Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom?

Helene Richter et al. Behav Brain Res. 2008.

Abstract

Several studies on both humans and animals reveal benefits of physical exercise on brain function and health. A previous study on TgCRND8 mice, a transgenic model of Alzheimer's disease, reported beneficial effects of premorbid onset of long-term access to a running wheel on spatial learning and plaque deposition. Our study investigated the effects of access to a running wheel after the onset of Abeta pathology on behavioural, endocrinological, and neuropathological parameters. From day 80 of age, the time when Abeta deposition becomes apparent, TgCRND8 and wildtype mice were kept with or without running wheel. Home cage behaviour was analysed and cognitive abilities regarding object recognition memory and spatial learning in the Barnes maze were assessed. Our results show that, in comparison to Wt mice, Tg mice were characterised by impaired object recognition memory and spatial learning, increased glucocorticoid levels, hyperactivity in the home cage and high levels of stereotypic behaviour. Access to a running wheel had no effects on cognitive or neuropathological parameters, but reduced the amount of stereotypic behaviour in transgenics significantly. Furthermore, wheel-running was inversely correlated with stereotypic behaviour, suggesting that wheel-running may have stereotypic qualities. In addition, wheel-running positively correlated with plaque burden. Thus, in a phase when plaques are already present in the brain, it may be symptomatic of brain pathology, rather than protective. Whether or not access to a running wheel has beneficial effects on Alzheimer-like pathology and symptoms may therefore strongly depend on the exact time when the wheel is provided during development of the disease.

PubMed Disclaimer

Similar articles

• Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice.
  Ambrée O, Touma C, Görtz N, Keyvani K, Paulus W, Palme R, Sachser N. Ambrée O, et al. Neurobiol Aging. 2006 Jul;27(7):955-64. doi: 10.1016/j.neurobiolaging.2005.05.009. Epub 2005 Jul 1. Neurobiol Aging. 2006. PMID: 15993515
• Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice.
  Görtz N, Lewejohann L, Tomm M, Ambrée O, Keyvani K, Paulus W, Sachser N. Görtz N, et al. Behav Brain Res. 2008 Aug 5;191(1):43-8. doi: 10.1016/j.bbr.2008.03.006. Epub 2008 Mar 14. Behav Brain Res. 2008. PMID: 18433890
• Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern.
  Melnikova T, Savonenko A, Wang Q, Liang X, Hand T, Wu L, Kaufmann WE, Vehmas A, Andreasson KI. Melnikova T, et al. Neuroscience. 2006 Sep 1;141(3):1149-62. doi: 10.1016/j.neuroscience.2006.05.001. Epub 2006 Jun 6. Neuroscience. 2006. PMID: 16753269
• [The lesions of Alzheimer's disease: which therapeutic perspectives?].
  Duyckaerts C, Perruchini C, Lebouvier T, Potier MC. Duyckaerts C, et al. Bull Acad Natl Med. 2008 Feb;192(2):303-18; discussion 318-21. Bull Acad Natl Med. 2008. PMID: 18819685 Review. French.
• Searching for new animal models of Alzheimer's disease.
  Epis R, Gardoni F, Marcello E, Genazzani A, Canonico PL, Di Luca M. Epis R, et al. Eur J Pharmacol. 2010 Jan 10;626(1):57-63. doi: 10.1016/j.ejphar.2009.10.020. Epub 2009 Oct 15. Eur J Pharmacol. 2010. PMID: 19836370 Review.

Cited by

• The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward.
  Novak CM, Burghardt PR, Levine JA. Novak CM, et al. Neurosci Biobehav Rev. 2012 Mar;36(3):1001-1014. doi: 10.1016/j.neubiorev.2011.12.012. Epub 2012 Jan 2. Neurosci Biobehav Rev. 2012. PMID: 22230703 Free PMC article. Review.
• Decreased rhythmic GABAergic septal activity and memory-associated theta oscillations after hippocampal amyloid-beta pathology in the rat.
  Villette V, Poindessous-Jazat F, Simon A, Léna C, Roullot E, Bellessort B, Epelbaum J, Dutar P, Stéphan A. Villette V, et al. J Neurosci. 2010 Aug 18;30(33):10991-1003. doi: 10.1523/JNEUROSCI.6284-09.2010. J Neurosci. 2010. PMID: 20720106 Free PMC article.
• Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.
  Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ. Webster SJ, et al. Front Genet. 2014 Apr 23;5:88. doi: 10.3389/fgene.2014.00088. eCollection 2014. Front Genet. 2014. PMID: 24795750 Free PMC article. Review.
• Clearance systems in the brain-implications for Alzheimer disease.
  Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. Tarasoff-Conway JM, et al. Nat Rev Neurol. 2015 Aug;11(8):457-70. doi: 10.1038/nrneurol.2015.119. Epub 2015 Jul 21. Nat Rev Neurol. 2015. PMID: 26195256 Free PMC article. Review.
• Exercise and Alzheimer's disease biomarkers in cognitively normal older adults.
  Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, Morris JC, Head D. Liang KY, et al. Ann Neurol. 2010 Sep;68(3):311-8. doi: 10.1002/ana.22096. Ann Neurol. 2010. PMID: 20818789 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Ovid Technologies, Inc.

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal