Cholinergic modulation of midbrain dopaminergic systems - PubMed (original) (raw)
Review
Cholinergic modulation of midbrain dopaminergic systems
J Mena-Segovia et al. Brain Res Rev. 2008 Aug.
Abstract
Dopamine neurons in the midbrain respond to behavioral events and environmental stimuli. Their different patterns of activation in turn modulate the activity of forebrain regions and modulate the expression of selective behavioral responses. However, their activity is closely dependent on the cholinergic systems in the brainstem. Ascending cholinergic projections from the pedunculopontine and laterodorsal tegmental nuclei target dopaminergic neurons in the substantia nigra compacta and ventral tegmental area following a topographical gradient. These projections, by means of the activation of acetylcholine receptors, influence the firing of dopamine neurons and therefore their responsiveness, ultimately affecting the release of dopamine in their forebrain targets. Brainstem cholinergic neurons are thus in a position to critically influence the activity of dopaminergic neurons in the midbrain, and thereby have a critical role in the expression of behavior.
Similar articles
- Characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups.
Oakman SA, Faris PL, Cozzari C, Hartman BK. Oakman SA, et al. Neuroscience. 1999;94(2):529-47. doi: 10.1016/s0306-4522(99)00307-3. Neuroscience. 1999. PMID: 10579214 - Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders.
Lester DB, Rogers TD, Blaha CD. Lester DB, et al. CNS Neurosci Ther. 2010 Jun;16(3):137-62. doi: 10.1111/j.1755-5949.2010.00142.x. Epub 2010 Mar 29. CNS Neurosci Ther. 2010. PMID: 20370804 Free PMC article. Review. - Midbrain muscarinic receptors modulate morphine-induced accumbal and striatal dopamine efflux in the rat.
Miller AD, Forster GL, Yeomans JS, Blaha CD. Miller AD, et al. Neuroscience. 2005;136(2):531-8. doi: 10.1016/j.neuroscience.2005.08.035. Epub 2005 Oct 10. Neuroscience. 2005. PMID: 16216430 - Forebrain projections from cholecystokininlike-immunoreactive neurons in the rat midbrain.
Seroogy KB, Fallon JH. Seroogy KB, et al. J Comp Neurol. 1989 Jan 15;279(3):415-35. doi: 10.1002/cne.902790307. J Comp Neurol. 1989. PMID: 2918078 - The electrophysiological actions of dopamine and dopaminergic drugs on neurons of the substantia nigra pars compacta and ventral tegmental area.
Mercuri NB, Calabresi P, Bernardi G. Mercuri NB, et al. Life Sci. 1992;51(10):711-8. doi: 10.1016/0024-3205(92)90479-9. Life Sci. 1992. PMID: 1355254 Review.
Cited by
- Cortico-Basal Ganglia reward network: microcircuitry.
Sesack SR, Grace AA. Sesack SR, et al. Neuropsychopharmacology. 2010 Jan;35(1):27-47. doi: 10.1038/npp.2009.93. Neuropsychopharmacology. 2010. PMID: 19675534 Free PMC article. Review. - Functional disconnection of the substantia nigra pars compacta from the pedunculopontine nucleus impairs learning of a conditioned avoidance task.
Bortolanza M, Wietzikoski EC, Boschen SL, Dombrowski PA, Latimer M, Maclaren DA, Winn P, Da Cunha C. Bortolanza M, et al. Neurobiol Learn Mem. 2010 Sep;94(2):229-39. doi: 10.1016/j.nlm.2010.05.011. Epub 2010 Jun 1. Neurobiol Learn Mem. 2010. PMID: 20595069 Free PMC article. - Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms.
Morikawa H, Paladini CA. Morikawa H, et al. Neuroscience. 2011 Dec 15;198:95-111. doi: 10.1016/j.neuroscience.2011.08.023. Epub 2011 Aug 16. Neuroscience. 2011. PMID: 21872647 Free PMC article. Review. - Putative cholinergic interneurons in the ventral and dorsal regions of the striatum have distinct roles in a two choice alternative association task.
Yarom O, Cohen D. Yarom O, et al. Front Syst Neurosci. 2011 May 31;5:36. doi: 10.3389/fnsys.2011.00036. eCollection 2011. Front Syst Neurosci. 2011. PMID: 21660109 Free PMC article. - Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area.
Oakman SA, Faris PL, Kerr PE, Cozzari C, Hartman BK. Oakman SA, et al. J Neurosci. 1995 Sep;15(9):5859-69. doi: 10.1523/JNEUROSCI.15-09-05859.1995. J Neurosci. 1995. PMID: 7666171 Free PMC article.