Enabling personalized cancer medicine through analysis of gene-expression patterns - PubMed (original) (raw)
Review
. 2008 Apr 3;452(7187):564-70.
doi: 10.1038/nature06915.
Affiliations
- PMID: 18385730
- DOI: 10.1038/nature06915
Review
Enabling personalized cancer medicine through analysis of gene-expression patterns
Laura J van't Veer et al. Nature. 2008.
Abstract
Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who require therapy and those who are most likely to benefit from certain therapies. In particular, tests that predict the clinical outcome for patients on the basis of the genes expressed by their tumours are likely to increasingly affect patient management, heralding a new era of personalized medicine.
Similar articles
- Personalized oncology: recent advances and future challenges.
Kalia M. Kalia M. Metabolism. 2013 Jan;62 Suppl 1:S11-4. doi: 10.1016/j.metabol.2012.08.016. Epub 2012 Sep 19. Metabolism. 2013. PMID: 22999010 Review. - Targeted therapy and pharmacogenomic programs.
Iqbal S, Lenz HJ. Iqbal S, et al. Cancer. 2003 Apr 15;97(8 Suppl):2076-82. doi: 10.1002/cncr.11287. Cancer. 2003. PMID: 12673699 Review. - Gene expression profiling as a tool for basic analysis and clinical application of human cancer.
García-Escudero R, Paramio JM. García-Escudero R, et al. Mol Carcinog. 2008 Aug;47(8):573-9. doi: 10.1002/mc.20430. Mol Carcinog. 2008. PMID: 18324660 - The cancer biomarker problem.
Sawyers CL. Sawyers CL. Nature. 2008 Apr 3;452(7187):548-52. doi: 10.1038/nature06913. Nature. 2008. PMID: 18385728 Review. - Missing the mark.
Gewin V. Gewin V. Nature. 2007 Oct 18;449(7164):770-1. doi: 10.1038/449770a. Nature. 2007. PMID: 17968417 No abstract available.
Cited by
- Ultrasound-responsive nanocarriers with siRNA and Fe3O4 regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy.
Li M, Li Y, Zheng J, Ma Z, Zhang J, Wu H, Zhu Y, Li P, Nie F. Li M, et al. J Nanobiotechnology. 2024 Oct 7;22(1):605. doi: 10.1186/s12951-024-02883-w. J Nanobiotechnology. 2024. PMID: 39375761 Free PMC article. - Recent development on statistical methods for personalized medicine discovery.
Zhao Y, Zeng D. Zhao Y, et al. Front Med. 2013 Mar;7(1):102-10. doi: 10.1007/s11684-013-0245-7. Epub 2013 Feb 2. Front Med. 2013. PMID: 23377890 Review. - Optimal Personalized Treatment Selection with Multivariate Outcome Measures in a Multiple Treatment Case.
Siriwardhana C, Kulasekera KB. Siriwardhana C, et al. Commun Stat Simul Comput. 2023;52(12):5773-5787. doi: 10.1080/03610918.2021.1999473. Epub 2021 Nov 15. Commun Stat Simul Comput. 2023. PMID: 38371330 Free PMC article. - Targeted Therapy Database (TTD): a model to match patient's molecular profile with current knowledge on cancer biology.
Mocellin S, Shrager J, Scolyer R, Pasquali S, Verdi D, Marincola FM, Briarava M, Gobbel R, Rossi C, Nitti D. Mocellin S, et al. PLoS One. 2010 Aug 10;5(8):e11965. doi: 10.1371/journal.pone.0011965. PLoS One. 2010. PMID: 20706624 Free PMC article. - Preparedness for colorectal cancer surgery and recovery through a person-centred information and communication intervention - A quasi-experimental longitudinal design.
Öhlén J, Sawatzky R, Pettersson M, Sarenmalm EK, Larsdotter C, Smith F, Wallengren C, Friberg F, Kodeda K, Carlsson E. Öhlén J, et al. PLoS One. 2019 Dec 12;14(12):e0225816. doi: 10.1371/journal.pone.0225816. eCollection 2019. PLoS One. 2019. PMID: 31830066 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous