Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy - PubMed (original) (raw)
Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy
Tamara Tilburgs et al. J Immunol. 2008.
Abstract
During pregnancy, the maternal immune system has to tolerate the persistence of fetal alloantigens. Many mechanisms contribute to the prevention of a destructive immune response mediated by maternal alloreactive lymphocytes directed against the allogeneic fetus. Murine studies suggest that CD4(+)CD25(+) T cells provide mechanisms of specific immune tolerance to fetal alloantigens during pregnancy. Previous studies by our group demonstrate that a significantly higher percentage of activated T cells and CD4(+)CD25(bright) T cells are present in decidual tissue in comparison with maternal peripheral blood in human pregnancy. In this study, we examined the phenotypic and functional properties of CD4(+)CD25(bright) T cells derived from maternal peripheral blood and decidual tissue. Depletion of CD4(+)CD25(bright) T cells from maternal peripheral blood demonstrates regulation to third party umbilical cord blood cells comparable to nonpregnant controls, whereas the suppressive capacity to umbilical cord blood cells of her own child is absent. Furthermore, maternal peripheral blood shows a reduced percentage of CD4(+)CD25(bright)FOXP3(+) and CD4(+)CD25(bright)HLA-DR(+) cells compared with peripheral blood of nonpregnant controls. In contrast, decidual lymphocyte isolates contain high percentages of CD4(+)CD25(bright) T cells with a regulatory phenotype that is able to down-regulate fetus-specific and fetus-nonspecific immune responses. These data suggest a preferential recruitment of fetus-specific regulatory T cells from maternal peripheral blood to the fetal-maternal interface, where they may contribute to the local regulation of fetus-specific responses.
Similar articles
- Differential distribution of CD4(+)CD25(bright) and CD8(+)CD28(-) T-cells in decidua and maternal blood during human pregnancy.
Tilburgs T, Roelen DL, van der Mast BJ, van Schip JJ, Kleijburg C, de Groot-Swings GM, Kanhai HH, Claas FH, Scherjon SA. Tilburgs T, et al. Placenta. 2006 Apr;27 Suppl A:S47-53. doi: 10.1016/j.placenta.2005.11.008. Epub 2006 Jan 25. Placenta. 2006. PMID: 16442616 - Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells.
Tilburgs T, Scherjon SA, van der Mast BJ, Haasnoot GW, Versteeg-V D Voort-Maarschalk M, Roelen DL, van Rood JJ, Claas FH. Tilburgs T, et al. J Reprod Immunol. 2009 Nov;82(2):148-57. doi: 10.1016/j.jri.2009.05.003. Epub 2009 Jul 23. J Reprod Immunol. 2009. PMID: 19631389 - Decidual CD8+CD28- T cells express CD103 but not perforin.
Tilburgs T, Scherjon SA, Roelen DL, Claas FH. Tilburgs T, et al. Hum Immunol. 2009 Feb;70(2):96-100. doi: 10.1016/j.humimm.2008.12.006. Epub 2009 Jan 14. Hum Immunol. 2009. PMID: 19150377 - The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus.
La Rocca C, Carbone F, Longobardi S, Matarese G. La Rocca C, et al. Immunol Lett. 2014 Nov;162(1 Pt A):41-8. doi: 10.1016/j.imlet.2014.06.013. Epub 2014 Jul 1. Immunol Lett. 2014. PMID: 24996040 Review. - The role of decidual immune cells on human pregnancy.
Liu S, Diao L, Huang C, Li Y, Zeng Y, Kwak-Kim JYH. Liu S, et al. J Reprod Immunol. 2017 Nov;124:44-53. doi: 10.1016/j.jri.2017.10.045. Epub 2017 Oct 18. J Reprod Immunol. 2017. PMID: 29055791 Review.
Cited by
- The role of viral infection in implantation failure: direct and indirect effects.
Rezaei M, Moghoofei M. Rezaei M, et al. Reprod Biol Endocrinol. 2024 Nov 11;22(1):142. doi: 10.1186/s12958-024-01303-w. Reprod Biol Endocrinol. 2024. PMID: 39529140 Free PMC article. Review. - Caerin 1.1 and 1.9 peptides halt B16 melanoma metastatic tumours via expanding cDC1 and reprogramming tumour macrophages.
Fu Q, Luo Y, Li J, Li H, Liu X, Chen Z, Ni G, Wang T. Fu Q, et al. J Transl Med. 2024 Oct 28;22(1):973. doi: 10.1186/s12967-024-05763-x. J Transl Med. 2024. PMID: 39468595 Free PMC article. - Development of a humanized mouse model with functional human materno-fetal interface immunity.
Dong S, Fu C, Shu C, Xie M, Li Y, Zou J, Meng YZ, Xu P, Shan YH, Tian HM, He J, Yang YG, Hu Z. Dong S, et al. JCI Insight. 2024 Oct 22;9(20):e176527. doi: 10.1172/jci.insight.176527. JCI Insight. 2024. PMID: 39435662 Free PMC article. - Impact of SARS-CoV-2 infection during pregnancy on the placenta and fetus.
Li A, Schwartz DA, Vo A, VanAbel R, Coler C, Li E, Lukman B, Del Rosario B, Vong A, Li M, Adams Waldorf KM. Li A, et al. Semin Perinatol. 2024 Jun;48(4):151919. doi: 10.1016/j.semperi.2024.151919. Epub 2024 Jun 6. Semin Perinatol. 2024. PMID: 38897829 Review. - HLA-G Expression/Secretion and T-Cell Cytotoxicity in Missed Abortion in Comparison to Normal Pregnancy.
Terzieva A, Alexandrova M, Manchorova D, Slavov S, Djerov L, Dimova T. Terzieva A, et al. Int J Mol Sci. 2024 Feb 24;25(5):2643. doi: 10.3390/ijms25052643. Int J Mol Sci. 2024. PMID: 38473890 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials