Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA - PubMed (original) (raw)
Comparative Study
. 1991 Nov 15;564(2):203-19.
doi: 10.1016/0006-8993(91)91456-b.
Affiliations
- PMID: 1839781
- DOI: 10.1016/0006-8993(91)91456-b
Comparative Study
Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA
M L Bouthenet et al. Brain Res. 1991.
Abstract
The messenger RNA (mRNA) of the recently characterized D3 dopamine receptor was visualized on rat brain sections using in situ hybridization with a 32P-labeled ribonucleic acid probe corresponding to a major part of the third cytoplasmic loop, a domain in which D2 and D3 dopamine receptors display little homology. For the purpose of comparison, D2 receptor mRNA was also specifically visualized on adjacent sections. The areas that expressed D2 and/or D3 receptors were also compared with those previously detected using [125I]iodosulpride, a ligand that binds to both D2 and D3 receptors with a similar affinity. The localization of D3 receptor mRNa markedly differs from that of D2 receptor mRNA. Whereas D2 receptor mRNA is expressed in all major brain areas receiving dopaminergic projections, particularly in the whole striatal complex, D3 receptor mRNA is expressed in a more restricted manner. It is mainly detected in telencephalic areas receiving dopaminergic inputs from the A10 cell group, e.g. accumbens nucleus, islands of Calleja, bed nucleus of the stria terminalis and other limbic areas such as the hippocampus and the mammillary nuclei. D2 and D3 receptor mRNAs were also detected at the level of the substantia nigra, suggesting that these receptors function as both autoreceptor and postsynaptic receptors. In several dopaminergic projection areas, e.g. ventral straitum, septal or mammillary nuclei, the distributions of D2 and D3 receptor mRNAs appeared complementary without overlap. The distribution of [125I]iodosulpride binding sites generally overlapped that of D2 or D3 receptor mRNAs, the latter being most abundant in dopaminergic areas known to be associated with cognitive and emotional functions.
Similar articles
- Visualization of dopamine D1, D2 and D3 receptor mRNAs in human and rat brain.
Mengod G, Villaró MT, Landwehrmeyer GB, Martinez-Mir MI, Niznik HB, Sunahara RK, Seeman P, O'Dowd BF, Probst A, Palacios JM. Mengod G, et al. Neurochem Int. 1992 Mar;20 Suppl:33S-43S. doi: 10.1016/0197-0186(92)90208-9. Neurochem Int. 1992. PMID: 1365451 - Differential visualization of dopamine D2 and D3 receptor sites in rat brain. A comparative study using in situ hybridization histochemistry and ligand binding autoradiography.
Landwehrmeyer B, Mengod G, Palacios JM. Landwehrmeyer B, et al. Eur J Neurosci. 1993 Feb 1;5(2):145-53. doi: 10.1111/j.1460-9568.1993.tb00480.x. Eur J Neurosci. 1993. PMID: 8261096 - Dopamine D2 and D3 receptors in the rat striatum and nucleus accumbens: use of 7-OH-DPAT and [125I]-iodosulpride.
Booze RM, Wallace DR. Booze RM, et al. Synapse. 1995 Jan;19(1):1-13. doi: 10.1002/syn.890190102. Synapse. 1995. PMID: 7709338 - Localization and function of the D3 dopamine receptor.
Sokoloff P, Giros B, Martres MP, Andrieux M, Besancon R, Pilon C, Bouthenet ML, Souil E, Schwartz JC. Sokoloff P, et al. Arzneimittelforschung. 1992 Feb;42(2A):224-30. Arzneimittelforschung. 1992. PMID: 1586393 Review. - D3 receptors and the actions of neuroleptics in the ventral striatopallidal system of schizophrenics.
Joyce JN, Gurevich EV. Joyce JN, et al. Ann N Y Acad Sci. 1999 Jun 29;877:595-613. doi: 10.1111/j.1749-6632.1999.tb09291.x. Ann N Y Acad Sci. 1999. PMID: 10415673 Review.
Cited by
- The novel antipsychotic cariprazine stabilizes gamma oscillations in rat hippocampal slices.
Meier MA, Lemercier CE, Kulisch C, Kiss B, Lendvai B, Adham N, Gerevich Z. Meier MA, et al. Br J Pharmacol. 2020 Apr;177(7):1622-1634. doi: 10.1111/bph.14923. Epub 2020 Feb 19. Br J Pharmacol. 2020. PMID: 31722437 Free PMC article. - Synthesis and pre-clinical evaluation of a potential radiotracer for PET imaging of the dopamine D3 receptor.
Stewart MN, Shao X, Desmond TJ, Forrest TJ, Arteaga J, Stauff J, Scott PJH. Stewart MN, et al. Medchemcomm. 2018 Jun 29;9(8):1315-1322. doi: 10.1039/c8md00094h. eCollection 2018 Aug 1. Medchemcomm. 2018. PMID: 30151086 Free PMC article. - Blockade of Intranigral and Systemic D3 Receptors Stimulates Motor Activity in the Rat Promoting a Reciprocal Interaction among Glutamate, Dopamine, and GABA.
Rodríguez-Sánchez M, Escartín-Pérez RE, Leyva-Gómez G, Avalos-Fuentes JA, Paz-Bermúdez FJ, Loya-López SI, Aceves J, Erlij D, Cortés H, Florán B. Rodríguez-Sánchez M, et al. Biomolecules. 2019 Sep 20;9(10):511. doi: 10.3390/biom9100511. Biomolecules. 2019. PMID: 31547016 Free PMC article. - Cocaine self-administration leads to alterations in temporal responses to cocaine challenge in limbic and motor circuitry.
Chen YI, Famous K, Xu H, Choi JK, Mandeville JB, Schmidt HD, Pierce RC, Jenkins BG. Chen YI, et al. Eur J Neurosci. 2011 Sep;34(5):800-15. doi: 10.1111/j.1460-9568.2011.07806.x. Eur J Neurosci. 2011. PMID: 21896062 Free PMC article. - Activation of human D3 dopamine receptor inhibits P/Q-type calcium channels and secretory activity in AtT-20 cells.
Kuzhikandathil EV, Oxford GS. Kuzhikandathil EV, et al. J Neurosci. 1999 Mar 1;19(5):1698-707. doi: 10.1523/JNEUROSCI.19-05-01698.1999. J Neurosci. 1999. PMID: 10024356 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases