Detection and prevalence patterns of group I coronaviruses in bats, northern Germany - PubMed (original) (raw)

doi: 10.3201/eid1404.071439.

Anne Ipsen, Antje Seebens, Matthias Göttsche, Marcus Panning, Jan Felix Drexler, Nadine Petersen, Augustina Annan, Klaus Grywna, Marcel Müller, Susanne Pfefferle, Christian Drosten

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Detection and prevalence patterns of group I coronaviruses in bats, northern Germany

Florian Gloza-Rausch et al. Emerg Infect Dis. 2008 Apr.

Abstract

We tested 315 bats from 7 different bat species in northern Germany for coronaviruses by reverse transcription-PCR. The overall prevalence was 9.8%. There were 4 lineages of group I coronaviruses in association with 4 different species of verspertilionid bats (Myotis dasycneme, M. daubentonii, Pipistrellus nathusii, P. pygmaeus). The lineages formed a monophyletic clade of bat coronaviruses found in northern Germany. The clade of bat coronaviruses have a sister relationship with a clade of Chinese type I coronaviruses that were also associated with the Myotis genus (M. ricketti). Young age and ongoing lactation, but not sex or existing gravidity, correlated significantly with coronavirus detection. The virus is probably maintained on the population level by amplification and transmission in maternity colonies, rather than being maintained in individual bats.

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Figures

Figure 1

Figure 1

Map of Germany (inset) with enlarged view of northern Germany. The study area is shaded, and dots in the study area indicate sampling sites.

Figure 2

Figure 2

Phlyogenetic analysis of northern German bat coronaviruses (CoV) (lineages 1–4) and related group I CoVs from bats and other mammals. Analyses were conducted in MEGA4 (32), by using the neighbor-joining algorithm with Kimura correction and a bootstrap test of phylogeny. Numbers at nodes denote bootstrap values as percentage of 1,000 repetitive analyses. The phylogeny is rooted with a Leopard CoV, ALC/GX/F230/06 (33). The column on the right shows bat CoV prototype strain names or the designations of type strains of established mammalian CoV species.

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References

    1. Gonzalez JM, Gomez-Puertas P, Cavanagh D, Gorbalenya AE, Enjuanes L. A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae. Arch Virol. 2003;148:2207–35. 10.1007/s00705-003-0162-1 - DOI - PMC - PubMed
    1. Cavanagh D. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch Virol. 1997;142:629–33. - PubMed
    1. van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJ, Wothers KC, et al. Identification of a new human coronavirus. Nat Med. 2004;10:368–73. 10.1038/nm1024 - DOI - PMC - PubMed
    1. Hamre D, Procknow JJ. A new virus isolated from the human respiratory tract. Proc Soc Exp Biol Med. 1966;121:190–3. - PubMed
    1. McIntosh K, Becker WB, Chanock RM. Growth in suckling-mouse brain of “IBV-like” viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci U S A. 1967;58:2268–73. 10.1073/pnas.58.6.2268 - DOI - PMC - PubMed

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