Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys - PubMed (original) (raw)

Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys

D H Abbott et al. Trends Endocrinol Metab. 1998 Feb.

Abstract

The developmental pathophysiology of polycystic ovary syndrome (PCOS) is unknown. However, prenatally androgenized female rhesus monkeys exhibit ovarian and endocrinological features that mimic those found in women with PCOS. Thus, prenatal androgen excess may provide an etiology for hyperandrogenism and anovulation in adulthood.

PubMed Disclaimer

Similar articles

• Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys.
  Abbott DH, Tarantal AF, Dumesic DA. Abbott DH, et al. Am J Primatol. 2009 Sep;71(9):776-84. doi: 10.1002/ajp.20679. Am J Primatol. 2009. PMID: 19367587 Free PMC article.
• Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome.
  Abbott DH, Zhou R, Bird IM, Dumesic DA, Conley AJ. Abbott DH, et al. Endocr Dev. 2008;13:145-158. doi: 10.1159/000134831. Endocr Dev. 2008. PMID: 18493139 Free PMC article. Review.
• Experimentally Induced Hyperinsulinemia Fails to Induce Polycystic Ovary Syndrome-like Traits in Female Rhesus Macaques.
  Zhou R, Bruns CM, Bird IM, Kemnitz JW, Dumesic DA, Abbott DH. Zhou R, et al. Int J Mol Sci. 2022 Feb 27;23(5):2635. doi: 10.3390/ijms23052635. Int J Mol Sci. 2022. PMID: 35269778 Free PMC article.
• Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
  Abbott DH, Barnett DK, Bruns CM, Dumesic DA. Abbott DH, et al. Hum Reprod Update. 2005 Jul-Aug;11(4):357-74. doi: 10.1093/humupd/dmi013. Hum Reprod Update. 2005. PMID: 15941725 Review.
• Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome.
  Zhou R, Bird IM, Dumesic DA, Abbott DH. Zhou R, et al. J Clin Endocrinol Metab. 2005 Dec;90(12):6630-7. doi: 10.1210/jc.2005-0691. Epub 2005 Sep 20. J Clin Endocrinol Metab. 2005. PMID: 16174719 Free PMC article.

Cited by

• Knowledge graph construction based on granulosa cells transcriptome from polycystic ovary syndrome with normoandrogen and hyperandrogen.
  Liu W, Tang T, Feng J, Wang C, Lin L, Wang S, Zeng K, Zou R, Yang Z, Zhao Y. Liu W, et al. J Ovarian Res. 2024 Feb 12;17(1):38. doi: 10.1186/s13048-024-01361-z. J Ovarian Res. 2024. PMID: 38347589 Free PMC article.
• Changes in circulating forms of anti-Muüllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy.
  Peigné M, Simon V, Pigny P, Mimouni NEH, Martin C, Dewailly D, Catteau-Jonard S, Giacobini P. Peigné M, et al. Hum Reprod. 2023 May 2;38(5):938-950. doi: 10.1093/humrep/dead050. Hum Reprod. 2023. PMID: 36921289 Free PMC article.
• Large animal models in the study of gynecological diseases.
  Cui M, Liu Y, Men X, Li T, Liu D, Deng Y. Cui M, et al. Front Cell Dev Biol. 2023 Jan 23;11:1110551. doi: 10.3389/fcell.2023.1110551. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36755972 Free PMC article. Review.
• Developmental programming of the neuroendocrine axis by steroid hormones: Insights from the sheep model of PCOS.
  Gurule S, Sustaita-Monroe J, Padmanabhan V, Cardoso R. Gurule S, et al. Front Endocrinol (Lausanne). 2023 Jan 23;14:1096187. doi: 10.3389/fendo.2023.1096187. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36755919 Free PMC article. Review.
• Prenatal exposure to acrylamide differently affected the sex ratio, aromatase and apoptosis in female adult offspring of two subsequent generations.
  Arafah M, Aldawood N, Alrezaki A, Nahdi S, Alwasel S, Mansour L, Harrath AH. Arafah M, et al. Physiol Res. 2023 Mar 8;72(1):59-69. doi: 10.33549/physiolres.934975. Epub 2022 Dec 22. Physiol Res. 2023. PMID: 36545876 Free PMC article.