Cellular life span and the Warburg effect - PubMed (original) (raw)

Review

. 2008 Jun 10;314(9):1923-8.

doi: 10.1016/j.yexcr.2008.03.007. Epub 2008 Mar 20.

Affiliations

• PMID: 18410925
• DOI: 10.1016/j.yexcr.2008.03.007

Review

Cellular life span and the Warburg effect

Hiroshi Kondoh. Exp Cell Res. 2008.

Abstract

Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo. Enhanced glycolysis is essential both in the step of immortalization and transformation, as it renders cells resistant to oxidative stress and adaptive to hypoxic condition, respectively. ES, immortalized primary, and cancerous cells display the common concerted metabolic shift, including enhanced glycolysis with reduced mitochondrial respiration by poorly characterized mechanism. Discovery of a novel regulatory mechanism for such a metabolic shift might be essential for the future development of cancer diagnosis and anti-cancer therapy.

PubMed Disclaimer

Similar articles

• Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.
  Wei YH, Wu SB, Ma YS, Lee HC. Wei YH, et al. Chang Gung Med J. 2009 Mar-Apr;32(2):113-32. Chang Gung Med J. 2009. PMID: 19403001 Review.
• The Warburg effect and mitochondrial stability in cancer cells.
  Gogvadze V, Zhivotovsky B, Orrenius S. Gogvadze V, et al. Mol Aspects Med. 2010 Feb;31(1):60-74. doi: 10.1016/j.mam.2009.12.004. Epub 2009 Dec 6. Mol Aspects Med. 2010. PMID: 19995572 Review.
• Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells.
  Ramalho-Santos J, Varum S, Amaral S, Mota PC, Sousa AP, Amaral A. Ramalho-Santos J, et al. Hum Reprod Update. 2009 Sep-Oct;15(5):553-72. doi: 10.1093/humupd/dmp016. Epub 2009 May 4. Hum Reprod Update. 2009. PMID: 19414527 Review.
• Mitochondria in cancer.
  Kroemer G. Kroemer G. Oncogene. 2006 Aug 7;25(34):4630-2. doi: 10.1038/sj.onc.1209589. Oncogene. 2006. PMID: 16892077
• Oxidative stress-mediated early senescence contributes to the short replicative life span of human peritoneal mesothelial cells.
  Ksiazek K, Mikuła-Pietrasik J, Jörres A, Witowski J. Ksiazek K, et al. Free Radic Biol Med. 2008 Aug 15;45(4):460-7. doi: 10.1016/j.freeradbiomed.2008.04.032. Epub 2008 May 1. Free Radic Biol Med. 2008. PMID: 18498775

Cited by

• An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells.
  Miyata S, Urabe M, Gomi A, Nagai M, Yamaguchi T, Tsukahara T, Mizukami H, Kume A, Ozawa K, Watanabe E. Miyata S, et al. Neurol Med Chir (Tokyo). 2013;53(10):645-54. doi: 10.2176/nmc.oa2012-0409. Epub 2013 Sep 27. Neurol Med Chir (Tokyo). 2013. PMID: 24077277 Free PMC article.
• Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect.
  Wiese EK, Hitosugi S, Loa ST, Sreedhar A, Andres-Beck LG, Kurmi K, Pang YP, Karnitz LM, Gonsalves WI, Hitosugi T. Wiese EK, et al. Nat Metab. 2021 Jul;3(7):954-968. doi: 10.1038/s42255-021-00424-5. Epub 2021 Jul 5. Nat Metab. 2021. PMID: 34226744 Free PMC article.
• Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury.
  Woodell A, Coughlin B, Kunchithapautham K, Casey S, Williamson T, Ferrell WD, Atkinson C, Jones BW, Rohrer B. Woodell A, et al. PLoS One. 2013 Jun 25;8(6):e67894. doi: 10.1371/journal.pone.0067894. Print 2013. PLoS One. 2013. PMID: 23825688 Free PMC article.
• The mitochondrial component of intracrine action.
  Re RN, Cook JL. Re RN, et al. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H577-83. doi: 10.1152/ajpheart.00421.2010. Epub 2010 Jul 9. Am J Physiol Heart Circ Physiol. 2010. PMID: 20622110 Free PMC article. Review.
• Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling.
  He H, Guo J, Hu Y, Zhang H, Li X, Zhang J, Jin S. He H, et al. Acta Biochim Biophys Sin (Shanghai). 2023 Jul 25;55(9):1404-1414. doi: 10.3724/abbs.2023040. Acta Biochim Biophys Sin (Shanghai). 2023. PMID: 37489008 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Ovid Technologies, Inc.