Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha - PubMed (original) (raw)
Review
. 2008 Jul 15;79(2):208-17.
doi: 10.1093/cvr/cvn098. Epub 2008 Apr 22.
Affiliations
- PMID: 18430751
- DOI: 10.1093/cvr/cvn098
Free article
Review
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha
Renée Ventura-Clapier et al. Cardiovasc Res. 2008.
Free article
Abstract
Although the concept of energy starvation in the failing heart was proposed decades ago, still very little is known about the origin of energetic failure. Recent advances in molecular biology have started to elucidate the transcriptional events governing mitochondrial biogenesis. In particular, a great step was taken with the discovery that peroxisome proliferator-activated receptor gamma co-activator (PGC-1alpha) is the master regulator of mitochondrial biogenesis. The molecular mechanisms underlying the downregulation of PGC-1alpha and the consequent decrease in mitochondrial function in heart failure are, however, still poorly understood. Indeed, the main pathways involved in mitochondrial biogenesis are thought to be up- rather than down-regulated in pathological hypertrophy and heart failure. The current review summarizes recent advances in this field and is restricted to the heart when cardiac data are available.
Similar articles
- Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.
Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP. Russell LK, et al. Circ Res. 2004 Mar 5;94(4):525-33. doi: 10.1161/01.RES.0000117088.36577.EB. Epub 2004 Jan 15. Circ Res. 2004. PMID: 14726475 - Control by circulating factors of mitochondrial function and transcription cascade in heart failure: a role for endothelin-1 and angiotensin II.
Garnier A, Zoll J, Fortin D, N'Guessan B, Lefebvre F, Geny B, Mettauer B, Veksler V, Ventura-Clapier R. Garnier A, et al. Circ Heart Fail. 2009 Jul;2(4):342-50. doi: 10.1161/CIRCHEARTFAILURE.108.812099. Epub 2009 May 8. Circ Heart Fail. 2009. PMID: 19808358 - [PGC-1alpha, a transcriptional coactivator involved in metabolism].
Tiraby C, Langin D. Tiraby C, et al. Med Sci (Paris). 2005 Jan;21(1):49-54. doi: 10.1051/medsci/200521149. Med Sci (Paris). 2005. PMID: 15639020 Review. French. - Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease.
Finck BN, Kelly DP. Finck BN, et al. Circulation. 2007 May 15;115(19):2540-8. doi: 10.1161/CIRCULATIONAHA.107.670588. Circulation. 2007. PMID: 17502589 No abstract available. - Punctum on two different transcription factors regulated by PGC-1α: nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2.
Baldelli S, Aquilano K, Ciriolo MR. Baldelli S, et al. Biochim Biophys Acta. 2013 Aug;1830(8):4137-46. doi: 10.1016/j.bbagen.2013.04.006. Epub 2013 Apr 15. Biochim Biophys Acta. 2013. PMID: 23597778 Review.
Cited by
- SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics.
Du Z, Zhou Y, Li Q, Xie Y, Zhu T, Qiao J, Zhang R, Bao Y, Wang L, Xie Y, Quan J, Lin M, Zhang N, Jin Q, Liang W, Wu L, Yin T, Xie Y. Du Z, et al. JACC Basic Transl Sci. 2024 Jul 31;9(10):1211-1230. doi: 10.1016/j.jacbts.2024.05.011. eCollection 2024 Oct. JACC Basic Transl Sci. 2024. PMID: 39534638 Free PMC article. - Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes.
Khan B, Lanzuolo C, Rosti V, Santarelli P, Pich A, Kraft T, Amrute-Nayak M, Nayak A. Khan B, et al. iScience. 2024 Sep 10;27(10):110913. doi: 10.1016/j.isci.2024.110913. eCollection 2024 Oct 18. iScience. 2024. PMID: 39386761 Free PMC article. - Targeting Mitochondrial Dysfunction for the Prevention and Treatment of Metabolic Disease by Bioactive Food Components.
Kim MB, Lee J, Lee JY. Kim MB, et al. J Lipid Atheroscler. 2024 Sep;13(3):306-327. doi: 10.12997/jla.2024.13.3.306. Epub 2024 Jun 17. J Lipid Atheroscler. 2024. PMID: 39355406 Free PMC article. Review. - Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific and individualized regulatory mechanisms.
Devine J, Monzel AS, Shire D, Rosenberg AM, Junker A, Cohen AA, Picard M. Devine J, et al. bioRxiv [Preprint]. 2024 Sep 22:2024.09.20.614152. doi: 10.1101/2024.09.20.614152. bioRxiv. 2024. PMID: 39345381 Free PMC article. Preprint. - Sex difference in human diseases: mechanistic insights and clinical implications.
Shi Y, Ma J, Li S, Liu C, Liu Y, Chen J, Liu N, Liu S, Huang H. Shi Y, et al. Signal Transduct Target Ther. 2024 Sep 10;9(1):238. doi: 10.1038/s41392-024-01929-7. Signal Transduct Target Ther. 2024. PMID: 39256355 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources