Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival - PubMed (original) (raw)
Review
doi: 10.1038/nrc2374.
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- PMID: 18432251
- DOI: 10.1038/nrc2374
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Review
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
H Llewelyn Roderick et al. Nat Rev Cancer. 2008 May.
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Abstract
Increases in cytosolic free Ca2+ ([Ca2+]i) represent a ubiquitous signalling mechanism that controls a variety of cellular processes, including proliferation, metabolism and gene transcription, yet under certain conditions increases in intracellular Ca2+ are cytotoxic. Thus, in using Ca2+ as a messenger, cells walk a tightrope in which [Ca2+]i is strictly maintained within defined boundaries. To adhere to these boundaries and to sustain their modified phenotype, many cancer cells remodel the expression or activity of their Ca2+ signalling apparatus. Here, we review the role of Ca2+ in promoting cell proliferation and cell death, how these processes are remodelled in cancer and the opportunities this might provide for therapeutic intervention.
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- BBS/E/B/0000C199/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
- C20001/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
- BBS/E/B/0000C197/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
- BHF_/British Heart Foundation/United Kingdom
- BBS/E/B/00001116/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
- BBS/E/B/0000C116/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
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