Acyclovir plus steroid vs steroid alone in the treatment of Bell's palsy - PubMed (original) (raw)
Randomized Controlled Trial
. 2008 May-Jun;29(3):163-6.
doi: 10.1016/j.amjoto.2007.05.001. Epub 2008 Mar 17.
Affiliations
- PMID: 18439948
- DOI: 10.1016/j.amjoto.2007.05.001
Randomized Controlled Trial
Acyclovir plus steroid vs steroid alone in the treatment of Bell's palsy
Seung Geun Yeo et al. Am J Otolaryngol. 2008 May-Jun.
Abstract
Purpose: The pathogenetic mechanism of Bell's palsy is thought to involve herpes simplex virus reactivation within the geniculate ganglion, followed by inflammation and entrapment of the nerve at the meatal foramen. We therefore compared the therapeutic effect of acyclovir plus steroid vs steroid alone, in combination with physical therapy, in patients with Bell's palsy.
Materials and methods: In a double-blind, randomized, prospective trial, 91 patients were randomized to treatment with acyclovir and prednisone (44 patients) or prednisone alone (47 patients). All patients underwent physical therapy. The follow-up period was greater than 6 months or encompassed the period of complete recovery from paralysis. House-Brackmann grade was evaluated 2 and 6 months after onset, with complete and satisfactory recovery defined as House-Brackmann grades I and II, respectively.
Results: The overall recovery rate of patients treated with steroid and acyclovir (93.1%) was greater than that of patients treated with steroid alone (85.1%), but the difference was not statistically significant.
Conclusion: The benefit of acyclovir in Bell's palsy has not been definitively established.
Comment in
- Acyclovir, steroids, and physiotherapy for the treatment of idiopathic facial palsy.
Teixeira LJ, do Prado GF. Teixeira LJ, et al. Am J Otolaryngol. 2009 Nov-Dec;30(6):435; author reply 435-6. doi: 10.1016/j.amjoto.2008.06.020. Epub 2009 Mar 6. Am J Otolaryngol. 2009. PMID: 19880037 No abstract available.
Similar articles
- Bell's palsy: a review of treatment using antiviral agents.
Alberton DL, Zed PJ. Alberton DL, et al. Ann Pharmacother. 2006 Oct;40(10):1838-42. doi: 10.1345/aph.1H077. Epub 2006 Sep 12. Ann Pharmacother. 2006. PMID: 16968821 Review. - Steroid-antiviral treatment improves the recovery rate in patients with severe Bell's palsy.
Lee HY, Byun JY, Park MS, Yeo SG. Lee HY, et al. Am J Med. 2013 Apr;126(4):336-41. doi: 10.1016/j.amjmed.2012.08.020. Epub 2013 Feb 6. Am J Med. 2013. PMID: 23394867 Clinical Trial. - The effect of study design and analysis methods on recovery rates in Bell's palsy.
Berg T, Marsk E, Engström M, Hultcrantz M, Hadziosmanovic N, Jonsson L. Berg T, et al. Laryngoscope. 2009 Oct;119(10):2046-50. doi: 10.1002/lary.20626. Laryngoscope. 2009. PMID: 19653268 Clinical Trial. - Reactivation of herpes simplex virus type 1 and varicella-zoster virus and therapeutic effects of combination therapy with prednisolone and valacyclovir in patients with Bell's palsy.
Kawaguchi K, Inamura H, Abe Y, Koshu H, Takashita E, Muraki Y, Matsuzaki Y, Nishimura H, Ishikawa H, Fukao A, Hongo S, Aoyagi M. Kawaguchi K, et al. Laryngoscope. 2007 Jan;117(1):147-56. doi: 10.1097/01.mlg.0000248737.65607.9e. Laryngoscope. 2007. PMID: 17202945 Clinical Trial. - Bell's palsy: does anything help?
Hickey J. Hickey J. Can Fam Physician. 2000 Jun;46:1293. Can Fam Physician. 2000. PMID: 10907567 Free PMC article. Review. No abstract available.
Cited by
- Optimal Bell's Palsy Treatment: Steroids, Antivirals, and a Timely and Personalized Approach.
Rim HS, Byun JY, Kim SH, Yeo SG. Rim HS, et al. J Clin Med. 2023 Dec 21;13(1):51. doi: 10.3390/jcm13010051. J Clin Med. 2023. PMID: 38202059 Free PMC article. - Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection.
Guo X, An Y, Tan W, Ma L, Wang M, Li J, Li B, Hou W, Wu L. Guo X, et al. Front Microbiol. 2023 Jun 5;14:1201505. doi: 10.3389/fmicb.2023.1201505. eCollection 2023. Front Microbiol. 2023. PMID: 37342565 Free PMC article. - Antiviral treatment for Bell's palsy (idiopathic facial paralysis).
Gagyor I, Madhok VB, Daly F, Sullivan F. Gagyor I, et al. Cochrane Database Syst Rev. 2019 Sep 5;9(9):CD001869. doi: 10.1002/14651858.CD001869.pub9. Cochrane Database Syst Rev. 2019. PMID: 31486071 Free PMC article. - Bell's Palsy in Children (BellPIC): protocol for a multicentre, placebo-controlled randomized trial.
Babl FE, Mackay MT, Borland ML, Herd DW, Kochar A, Hort J, Rao A, Cheek JA, Furyk J, Barrow L, George S, Zhang M, Gardiner K, Lee KJ, Davidson A, Berkowitz R, Sullivan F, Porrello E, Dalziel KM, Anderson V, Oakley E, Hopper S, Williams F, Wilson C, Williams A, Dalziel SR; PREDICT (Paediatric Research In Emergency Departments International Collaborative) research network. Babl FE, et al. BMC Pediatr. 2017 Feb 13;17(1):53. doi: 10.1186/s12887-016-0702-y. BMC Pediatr. 2017. PMID: 28193257 Free PMC article. Clinical Trial. - Facial Palsy, a Disorder Belonging to Influential Neurological Dynasty: Review of Literature.
Newadkar UR, Chaudhari L, Khalekar YK. Newadkar UR, et al. N Am J Med Sci. 2016 Jul;8(7):263-7. doi: 10.4103/1947-2714.187130. N Am J Med Sci. 2016. PMID: 27583233 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical