Mammalian complex I: a regulable and vulnerable pacemaker in mitochondrial respiratory function - PubMed (original) (raw)
. 2008 Jul-Aug;1777(7-8):719-28.
doi: 10.1016/j.bbabio.2008.04.005. Epub 2008 Apr 11.
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- PMID: 18455500
- DOI: 10.1016/j.bbabio.2008.04.005
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Mammalian complex I: a regulable and vulnerable pacemaker in mitochondrial respiratory function
Sergio Papa et al. Biochim Biophys Acta. 2008 Jul-Aug.
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Abstract
In this paper the regulatory features of complex I of mammalian and human mitochondria are reviewed. In a variety of mitotic cell-line cultures, activation in vivo of the cAMP cascade, or direct addition of cAMP, promotes the NADH-ubiquinone oxidoreductase activity of complex I and lower the cellular level of ROS. These effects of cAMP are found to be associated with PKA-mediated serine phosphorylation in the conserved C-terminus of the subunit of complex I encoded by the nuclear gene NDUFS4. PKA mediated phosphorylation of this Ser in the C-terminus of the protein promotes its mitochondrial import and maturation. Mass-spectrometry analysis of the phosphorylation pattern of complex I subunits is also reviewed.
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