Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study - PubMed (original) (raw)

Multicenter Study

Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study

Caroline S Fox et al. Diabetes Care. 2008 Aug.

Abstract

Objective: We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes.

Research design and methods: Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years.

Results: Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men.

Conclusions: The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.

PubMed Disclaimer

Similar articles

• Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity.
  Khan SS, Ning H, Wilkins JT, Allen N, Carnethon M, Berry JD, Sweis RN, Lloyd-Jones DM. Khan SS, et al. JAMA Cardiol. 2018 Apr 1;3(4):280-287. doi: 10.1001/jamacardio.2018.0022. JAMA Cardiol. 2018. PMID: 29490333 Free PMC article.
• Lifetime risk and years lived free of total cardiovascular disease.
  Wilkins JT, Ning H, Berry J, Zhao L, Dyer AR, Lloyd-Jones DM. Wilkins JT, et al. JAMA. 2012 Nov 7;308(17):1795-801. doi: 10.1001/jama.2012.14312. JAMA. 2012. PMID: 23117780 Free PMC article.
• Adult obesity and number of years lived with and without cardiovascular disease.
  Pardo Silva MC, De Laet C, Nusselder WJ, Mamun AA, Peeters A. Pardo Silva MC, et al. Obesity (Silver Spring). 2006 Jul;14(7):1264-73. doi: 10.1038/oby.2006.144. Obesity (Silver Spring). 2006. PMID: 16899808
• Obesity, diabetes, and risk of cardiovascular disease in the elderly.
  Wilson PW, Kannel WB. Wilson PW, et al. Am J Geriatr Cardiol. 2002 Mar-Apr;11(2):119-23,125. doi: 10.1111/j.1076-7460.2002.00998.x. Am J Geriatr Cardiol. 2002. PMID: 11872970 Review.
• Insulin resistance: the link between obesity and cardiovascular disease.
  Reaven GM. Reaven GM. Med Clin North Am. 2011 Sep;95(5):875-92. doi: 10.1016/j.mcna.2011.06.002. Med Clin North Am. 2011. PMID: 21855697 Review.

Cited by

• Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review.
  Dabbaghi MM, Soleimani Roudi H, Safaei R, Baradaran Rahimi V, Fadaei MR, Askari VR. Dabbaghi MM, et al. Cardiovasc Toxicol. 2024 Sep 22. doi: 10.1007/s12012-024-09921-x. Online ahead of print. Cardiovasc Toxicol. 2024. PMID: 39306819 Review.
• Genomic risk prediction of cardiovascular diseases among type 2 diabetes patients in the UK Biobank.
  Ye Y, Hu J, Pang F, Cui C, Zhao H. Ye Y, et al. Front Bioinform. 2024 Jan 4;3:1320748. doi: 10.3389/fbinf.2023.1320748. eCollection 2023. Front Bioinform. 2024. PMID: 38239805 Free PMC article.
• Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention.
  Jones JE, Tang KS, Barseghian A, Wong ND. Jones JE, et al. J Clin Med. 2023 Nov 30;12(23):7432. doi: 10.3390/jcm12237432. J Clin Med. 2023. PMID: 38068483 Free PMC article. Review.
• The lifetime risk of developing type II diabetes in an urban community in Mumbai: findings from a ten-year retrospective cohort study.
  Sharma P, Dilip TR, Mishra US, Kulkarni A. Sharma P, et al. BMC Public Health. 2023 Aug 31;23(1):1673. doi: 10.1186/s12889-023-16596-6. BMC Public Health. 2023. PMID: 37653484 Free PMC article.
• Effect of Urinary Albumin Creatinine Ratio on Cardiovascular Morbidity and Mortality in Diabetes Patients with Atherosclerotic Disease.
  Gao F, Zhou Y, Yan X, Huang H, Liang G, Xie Y, Zhu Q, Chen Z, Wang B, Li H, Mai Z, Ying M, Liu J, Chen S, Chen J. Gao F, et al. Diabetes Metab Syndr Obes. 2023 Mar 17;16:819-828. doi: 10.2147/DMSO.S400970. eCollection 2023. Diabetes Metab Syndr Obes. 2023. PMID: 36959900 Free PMC article.

References

1. 1. Leibson CL, Williamson DF, Melton LJ 3rd, Palumbo PJ, Smith SA, Ransom JE, Schilling PL, Narayan KM: Temporal trends in BMI among adults with diabetes. Diabetes Care 24:1584–1589, 2001 - PubMed
2. 1. Lloyd-Jones DM, Larson MG, Beiser A, Levy D: Lifetime risk of developing coronary heart disease. Lancet 353:89–92, 1999 - PubMed
3. 1. Lloyd-Jones DM, Leip EP, Larson MG, D’Agostino RB, Beiser A, Wilson PW, Wolf PA, Levy D: Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation 113:791–798, 2006 - PubMed
4. 1. Beiser A, D’Agostino RB Sr, Seshadri S, Sullivan LM, Wolf PA: Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study: the Practical Incidence Estimators (PIE) macro. Stat Med 19:1495–1522, 2000 - PubMed
5. 1. Gaynor JJ, Feuer EJ, Tan CC, Wu DH, Little CR, Straus DJ, Clarkson BD, Brennan MF: On the use of cause-specific failure and conditional failure probabilities—examples from clinical oncology data. J Am Stat Assoc 88:400–409, 1993

Publication types

MeSH terms

Grants and funding

• K24 HL004334/HL/NHLBI NIH HHS/United States
• N01HC25195/HL/NHLBI NIH HHS/United States
• K24 HL04334/HL/NHLBI NIH HHS/United States
• N01-HC-25195/HC/NHLBI NIH HHS/United States

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central
  • Silverchair Information Systems

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information