Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals - PubMed (original) (raw)
. 2008 Jun 1;18(11):3206-10.
doi: 10.1016/j.bmcl.2008.04.060. Epub 2008 Apr 26.
Affiliations
- PMID: 18468894
- DOI: 10.1016/j.bmcl.2008.04.060
Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals
Yuichi Masuda et al. Bioorg Med Chem Lett. 2008.
Abstract
Structural analysis of 42-residue amyloid beta (Abeta42) aggregates using rotational resonance in solid-state NMR verified that C(beta) and/or C(gamma) of Met-35 and the carboxyl carbon of Ala-42 are proximal enough to form an intramolecular antiparallel beta-sheet in the C-terminus. The S-oxidized radical cation at Met-35, an ultimate radical species responsible for neurotoxicity, could be stabilized by the carboxylate anion at the C-terminus, resulting in aggregation to cause long-term oxidative stress.
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