Interstitial chromosomal deletion within 4q11-q13 in a human hepatoma cell line - PubMed (original) (raw)
. 1991 Mar 1;51(5):1460-4.
Affiliations
- PMID: 1847664
Interstitial chromosomal deletion within 4q11-q13 in a human hepatoma cell line
Y Urano et al. Cancer Res. 1991.
Abstract
Southern blot analysis revealed the presence of an aberrant albumin gene as well as a normal one in a human hepatoma cell line, HuH-7. A genomic sequence carrying this altered gene was isolated and characterized. This clone contains a 3-kbp 3' segment of the albumin gene linked to a non-albumin sequence at intron 11. The non-albumin sequence is assigned to chromosome 4q12-q13 by in situ hybridization. This indicates an interstitial deletion of a chromosomal segment within 4q11-q13 because the albumin gene is mapped there. The truncated albumin gene is detected in an early passage of HuH-7 cells and has been maintained stably in cell culture.
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