Assessing the role of p-cresol tolerance in Clostridium difficile - PubMed (original) (raw)
. 2008 Jun;57(Pt 6):745-749.
doi: 10.1099/jmm.0.47744-0.
Affiliations
- PMID: 18480332
- DOI: 10.1099/jmm.0.47744-0
Assessing the role of p-cresol tolerance in Clostridium difficile
Lisa F Dawson et al. J Med Microbiol. 2008 Jun.
Abstract
Clostridium difficile is an important nosocomial pathogen, resulting in antibiotic-associated disease ranging from mild diarrhoea to the life-threatening pseudomembranous colitis. Upon antibiotic exposure, it is believed that the normal bowel microflora of patients is disrupted, allowing C. difficile to proliferate. Significantly, C. difficile is among only a few bacteria able to ferment tyrosine to p-cresol, a phenolic compound that is toxic to other microbes via its ability to interfere with metabolism. Therefore, the ability of different C. difficile strains to produce and tolerate p-cresol may play an important role in the development and severity of C. difficile-associated disease. In this study, it was demonstrated that two C. difficile hypervirulent 027 strains (Stoke Mandeville and BI-16) are more tolerant to p-cresol than other C. difficile strains including 630, CF4 and CD196. Surprising, it was shown that Clostridium sordellii also has a high tolerance to p-cresol, suggesting an overlap in the tolerance pathways in these clostridial species.
Similar articles
- The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains.
Dawson LF, Donahue EH, Cartman ST, Barton RH, Bundy J, McNerney R, Minton NP, Wren BW. Dawson LF, et al. BMC Microbiol. 2011 Apr 28;11:86. doi: 10.1186/1471-2180-11-86. BMC Microbiol. 2011. PMID: 21527013 Free PMC article. - Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria.
Passmore IJ, Letertre MPM, Preston MD, Bianconi I, Harrison MA, Nasher F, Kaur H, Hong HA, Baines SD, Cutting SM, Swann JR, Wren BW, Dawson LF. Passmore IJ, et al. PLoS Pathog. 2018 Sep 12;14(9):e1007191. doi: 10.1371/journal.ppat.1007191. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30208103 Free PMC article. - In vitro inhibition of Clostridium difficile and Clostridium perfringens by commercial probiotic strains.
Schoster A, Kokotovic B, Permin A, Pedersen PD, Dal Bello F, Guardabassi L. Schoster A, et al. Anaerobe. 2013 Apr;20:36-41. doi: 10.1016/j.anaerobe.2013.02.006. Epub 2013 Mar 5. Anaerobe. 2013. PMID: 23471038 - Clostridium difficile-associated diarrhoea.
Elliott B, Chang BJ, Golledge CL, Riley TV. Elliott B, et al. Intern Med J. 2007 Aug;37(8):561-8. doi: 10.1111/j.1445-5994.2007.01403.x. Intern Med J. 2007. PMID: 17640189 Review. - Clostridium difficile, the Difficult "Kloster" Fuelled by Antibiotics.
Dicks LMT, Mikkelsen LS, Brandsborg E, Marcotte H. Dicks LMT, et al. Curr Microbiol. 2019 Jun;76(6):774-782. doi: 10.1007/s00284-018-1543-8. Epub 2018 Aug 6. Curr Microbiol. 2019. PMID: 30084095 Review.
Cited by
- _p_-Cresol Sulfate Is a Sensitive Urinary Marker of Fecal Microbiota Transplantation and Antibiotics Treatments in Human Patients and Mouse Models.
Zhou Y, Bi Z, Hamilton MJ, Zhang L, Su R, Sadowsky MJ, Roy S, Khoruts A, Chen C. Zhou Y, et al. Int J Mol Sci. 2023 Sep 27;24(19):14621. doi: 10.3390/ijms241914621. Int J Mol Sci. 2023. PMID: 37834066 Free PMC article. - The role of microbiota in autism spectrum disorder: A bibliometric analysis based on original articles.
Lin X, Zhou R, Liang D, Xia L, Zeng L, Chen X. Lin X, et al. Front Psychiatry. 2022 Sep 12;13:976827. doi: 10.3389/fpsyt.2022.976827. eCollection 2022. Front Psychiatry. 2022. PMID: 36172516 Free PMC article. - Clostridioides difficile Infection Dysregulates Brain Dopamine Metabolism.
Vinithakumari AA, Padhi P, Hernandez B, Lin SJ, Dunkerson-Kurzhumov A, Showman L, Breitzman M, Stokes C, Sulaiman Y, Tangudu C, Kuttappan DA, Muyyarikkandy MS, Willette AA, Phillips GJ, Anantharam V, Perera A, Sponseller BA, Kanthasamy A, Mooyottu S. Vinithakumari AA, et al. Microbiol Spectr. 2022 Apr 27;10(2):e0007322. doi: 10.1128/spectrum.00073-22. Epub 2022 Mar 24. Microbiol Spectr. 2022. PMID: 35323033 Free PMC article. - Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder.
Liu J, Gao Z, Liu C, Liu T, Gao J, Cai Y, Fan X. Liu J, et al. Front Cell Dev Biol. 2022 Mar 3;10:792490. doi: 10.3389/fcell.2022.792490. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35309933 Free PMC article. Review. - The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review.
Zheng Y, Bek MK, Prince NZ, Peralta Marzal LN, Garssen J, Perez Pardo P, Kraneveld AD. Zheng Y, et al. Front Neurosci. 2021 Oct 21;15:738220. doi: 10.3389/fnins.2021.738220. eCollection 2021. Front Neurosci. 2021. PMID: 34744609 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical