T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites - PubMed (original) (raw)

doi: 10.1038/nn.2124. Epub 2008 May 18.

Affiliations

• PMID: 18488023
• DOI: 10.1038/nn.2124

T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites

Lucius Cueni et al. Nat Neurosci. 2008 Jun.

Abstract

T-type Ca2+ channels (T channels) underlie rhythmic burst discharges during neuronal oscillations that are typical during sleep. However, the Ca2+-dependent effectors that are selectively regulated by T currents remain unknown. We found that, in dendrites of nucleus reticularis thalami (nRt), intracellular Ca2+ concentration increases were dominated by Ca2+ influx through T channels and shaped rhythmic bursting via competition between Ca2+-dependent small-conductance (SK)-type K+ channels and Ca2+ uptake pumps. Oscillatory bursting was initiated via selective activation of dendritically located SK2 channels, whereas Ca2+ sequestration by sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs) and cumulative T channel inactivation dampened oscillations. Sk2-/- (also known as Kcnn2) mice lacked cellular oscillations, showed a greater than threefold reduction in low-frequency rhythms in the electroencephalogram of non-rapid-eye-movement sleep and had disrupted sleep. Thus, the interplay of T channels, SK2 channels and SERCAs in nRt dendrites comprises a specialized Ca2+ signaling triad to regulate oscillatory dynamics related to sleep.

PubMed Disclaimer

Similar articles

• Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release.
  Coulon P, Herr D, Kanyshkova T, Meuth P, Budde T, Pape HC. Coulon P, et al. Cell Calcium. 2009 Nov-Dec;46(5-6):333-46. doi: 10.1016/j.ceca.2009.09.005. Epub 2009 Nov 14. Cell Calcium. 2009. PMID: 19913909
• Two pathways for the activation of small-conductance potassium channels in neurons of substantia nigra pars reticulata.
  Yanovsky Y, Zhang W, Misgeld U. Yanovsky Y, et al. Neuroscience. 2005;136(4):1027-36. doi: 10.1016/j.neuroscience.2005.08.026. Epub 2005 Oct 3. Neuroscience. 2005. PMID: 16203104
• Heterogeneity in low voltage-activated Ca2+ channel-evoked Ca2+ responses within neurons of the thalamic paraventricular nucleus.
  Richter TA, Kolaj M, Renaud LP. Richter TA, et al. Eur J Neurosci. 2006 Sep;24(5):1316-24. doi: 10.1111/j.1460-9568.2006.05004.x. Epub 2006 Sep 8. Eur J Neurosci. 2006. PMID: 16965551
• T-type calcium channels and tumor proliferation.
  Panner A, Wurster RD. Panner A, et al. Cell Calcium. 2006 Aug;40(2):253-9. doi: 10.1016/j.ceca.2006.04.029. Epub 2006 Jun 12. Cell Calcium. 2006. PMID: 16765439 Review.
• SK channels in excitability, pacemaking and synaptic integration.
  Bond CT, Maylie J, Adelman JP. Bond CT, et al. Curr Opin Neurobiol. 2005 Jun;15(3):305-11. doi: 10.1016/j.conb.2005.05.001. Curr Opin Neurobiol. 2005. PMID: 15922588 Review.

Cited by

• GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons.
  Sun YG, Wu CS, Renger JJ, Uebele VN, Lu HC, Beierlein M. Sun YG, et al. J Neurosci. 2012 Jun 6;32(23):7782-90. doi: 10.1523/JNEUROSCI.0839-12.2012. J Neurosci. 2012. PMID: 22674255 Free PMC article.
• A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels.
  Chemin J, Stamenic TT, Cazade M, Llinares J, Blesneac I, Todorovic SM, Lory P. Chemin J, et al. Sci Rep. 2019 Oct 30;9(1):15642. doi: 10.1038/s41598-019-52194-6. Sci Rep. 2019. PMID: 31666636 Free PMC article.
• Dendritic ion channel trafficking and plasticity.
  Shah MM, Hammond RS, Hoffman DA. Shah MM, et al. Trends Neurosci. 2010 Jul;33(7):307-16. doi: 10.1016/j.tins.2010.03.002. Epub 2010 Apr 1. Trends Neurosci. 2010. PMID: 20363038 Free PMC article. Review.
• Dendritic T-type Ca2+ channels: giving a boost to thalamic reticular neurons.
  Errington AC, Connelly WM. Errington AC, et al. J Neurosci. 2011 Apr 13;31(15):5551-3. doi: 10.1523/JNEUROSCI.0067-11.2011. J Neurosci. 2011. PMID: 21490193 Free PMC article. No abstract available.
• The sleep relay--the role of the thalamus in central and decentral sleep regulation.
  Coulon P, Budde T, Pape HC. Coulon P, et al. Pflugers Arch. 2012 Jan;463(1):53-71. doi: 10.1007/s00424-011-1014-6. Epub 2011 Sep 13. Pflugers Arch. 2012. PMID: 21912835 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal