Regulated import and degradation of a cytosolic protein in the yeast vacuole - PubMed (original) (raw)
. 1991 Mar 28;350(6316):313-8.
doi: 10.1038/350313a0.
Affiliations
- PMID: 1848921
- DOI: 10.1038/350313a0
Regulated import and degradation of a cytosolic protein in the yeast vacuole
H L Chiang et al. Nature. 1991.
Abstract
The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.
Comment in
- Site of catabolite inactivation.
Schork SM, Bee G, Thumm M, Wolf DH. Schork SM, et al. Nature. 1994 May 26;369(6478):283-4. doi: 10.1038/369283a0. Nature. 1994. PMID: 8183364 No abstract available.
Similar articles
- In vitro reconstitution of glucose-induced targeting of fructose-1, 6-bisphosphatase into the vacuole in semi-intact yeast cells.
Shieh HL, Chiang HL. Shieh HL, et al. J Biol Chem. 1998 Feb 6;273(6):3381-7. doi: 10.1074/jbc.273.6.3381. J Biol Chem. 1998. PMID: 9452458 - Biochemical analysis of fructose-1,6-bisphosphatase import into vacuole import and degradation vesicles reveals a role for UBC1 in vesicle biogenesis.
Shieh HL, Chen Y, Brown CR, Chiang HL. Shieh HL, et al. J Biol Chem. 2001 Mar 30;276(13):10398-406. doi: 10.1074/jbc.M001767200. Epub 2000 Dec 29. J Biol Chem. 2001. PMID: 11134048 - Proteolytic catabolite inactivation in Saccharomyces cerevisiae.
Holzer H. Holzer H. Revis Biol Celular. 1989;21:305-19. Revis Biol Celular. 1989. PMID: 2561496 Review.
Cited by
- The Role of Deubiquitinating Enzymes in the Various Forms of Autophagy.
Csizmadia T, Lőw P. Csizmadia T, et al. Int J Mol Sci. 2020 Jun 12;21(12):4196. doi: 10.3390/ijms21124196. Int J Mol Sci. 2020. PMID: 32545524 Free PMC article. Review. - Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction.
Giardina BJ, Dunton D, Chiang HL. Giardina BJ, et al. J Biol Chem. 2013 Apr 26;288(17):11636-48. doi: 10.1074/jbc.M112.419895. Epub 2013 Feb 7. J Biol Chem. 2013. PMID: 23393132 Free PMC article. - The TOR complex 1 is required for the interaction of multiple cargo proteins selected for the vacuole import and degradation pathway.
Alibhoy AA, Chiang HL. Alibhoy AA, et al. Commun Integr Biol. 2010 Nov;3(6):594-6. doi: 10.4161/cib.3.6.13241. Epub 2010 Nov 1. Commun Integr Biol. 2010. PMID: 21331250 Free PMC article. - The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation.
Brown CR, Dunton D, Chiang HL. Brown CR, et al. J Biol Chem. 2010 Jan 8;285(2):1516-28. doi: 10.1074/jbc.M109.028241. Epub 2009 Nov 5. J Biol Chem. 2010. PMID: 19892709 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases