A complex RNA sequence determines the internal initiation of encephalomyocarditis virus RNA translation - PubMed (original) (raw)
A complex RNA sequence determines the internal initiation of encephalomyocarditis virus RNA translation
A G Evstafieva et al. Nucleic Acids Res. 1991.
Free PMC article
Erratum in
- Nucleic Acids Res 1991 Mar 25;19(6):1358
Abstract
Translation initiation on EMCV RNA occurs via binding of ribosomes to an internal sequence within the 5' noncoding region. To investigate the organization of the internal ribosome entry site (IRES) we have determined the translational efficiencies of a series of deletion mutants within the 5' noncoding region of EMCV RNA. Three functional regions have been distinguished: a sequence between nts 315-484 and the upper parts of the double-helical structural domains III (nts 488-647) and IV (nts 701-763). The first one greatly enhances translation, but is not absolutely necessary for internal initiation. The other two regions are indispensable to this process. A sequence within domain IV determines inhibition of in vitro translation of mRNAs with 5'-terminal dependent initiation. It is proposed to interact with a translational factor(s) common to the internal and 5'-terminal dependent initiation.
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References
- J Virol. 1989 Apr;63(4):1651-60 - PubMed
- Science. 1988 Jul 22;241(4864):445-8 - PubMed
- J Virol. 1988 Jul;62(7):2219-27 - PubMed
- Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8 - PubMed
- J Virol. 1988 Jul;62(7):2291-9 - PubMed
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