Erectile dysfunction predicts coronary heart disease in type 2 diabetes - PubMed (original) (raw)
. 2008 May 27;51(21):2045-50.
doi: 10.1016/j.jacc.2008.02.051.
Affiliations
- PMID: 18498959
- DOI: 10.1016/j.jacc.2008.02.051
Free article
Erectile dysfunction predicts coronary heart disease in type 2 diabetes
Ronald Ching-Wan Ma et al. J Am Coll Cardiol. 2008.
Free article
Abstract
Objectives: We examined the predictive power of erectile dysfunction (ED) on coronary heart disease (CHD) events in Chinese men with type 2 diabetes.
Background: Subjects with diabetes are prone to develop cardiovascular complications. Erectile dysfunction is strongly associated with CHD in cross-sectional studies, but prospective data are lacking.
Methods: A consecutive cohort of men with no clinical evidence of cardiovascular disease underwent comprehensive assessments for diabetic complications. Erectile dysfunction was defined according to the definition of the National Institutes of Health Consensus Conference 1992. Coronary heart disease events were censored with centralized territory-wide hospital databases in 2005.
Results: Of 2,306 subjects (age: 54.2 +/- 12.7 years; follow-up: 4.0 [range 1.7 to 7.1] years), 26.7% had ED at baseline. The incidence of CHD events was higher in men with ED than those without (19.7/1,000 person-years, 95% confidence interval [CI] 14.3 to 25.2 person-years vs. 9.5/1,000 person-years, 95% CI 7.4 to 11.7 person-years). Men who developed CHD events were older; had a higher frequency of ED and microvascular complications; had longer duration of diabetes; and had higher blood pressure, total cholesterol, low-density lipoprotein cholesterol, and urinary albumin/creatinine ratio but lower high-density lipoprotein cholesterol and estimated glomerular filtration rate than those without CHD events. Erectile dysfunction remained an independent predictor for CHD events (hazard ratio 1.58, 95% CI 1.08 to 2.30, p = 0.018) after adjustment for other covariates along with age, duration of disease, and use of antihypertensive agents and albuminuria.
Conclusions: In type 2 diabetic men without clinically overt cardiovascular disease, the presence of ED predicts a new onset of CHD events. Symptoms of ED should be independently sought to identify high-risk subjects for comprehensive cardiovascular assessments.
Comment in
- Erectile dysfunction: the new harbinger for major adverse cardiac events in the diabetic patient.
Kloner RA. Kloner RA. J Am Coll Cardiol. 2008 May 27;51(21):2051-2. doi: 10.1016/j.jacc.2007.11.084. J Am Coll Cardiol. 2008. PMID: 18498960 No abstract available.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical