CC chemokine receptor 5 gene promoter activation by the cyclic AMP response element binding transcription factor - PubMed (original) (raw)
. 2008 Sep 1;112(5):1610-9.
doi: 10.1182/blood-2008-01-135111. Epub 2008 May 29.
Affiliations
- PMID: 18511806
- DOI: 10.1182/blood-2008-01-135111
Free article
CC chemokine receptor 5 gene promoter activation by the cyclic AMP response element binding transcription factor
Hedwich F Kuipers et al. Blood. 2008.
Free article
Abstract
The chemokine receptor CCR5 is implicated in the pathogenesis of various inflammatory diseases, such as multiple sclerosis (MS), atherosclerosis, transplant rejection, and autoimmunity. In previous studies, we have shown that MS lesions are characterized by enhanced expression of transcription factors associated with stress responses, ie, IRF-1, NF-kappaB, and CREB-1, which modulate expression of both classes of major histocompatibility complex (MHC) molecules. The expression of MHC-I and MHC-II molecules greatly overlaps with the expression of CCR5 in MS lesions. Therefore, we investigated whether these factors are also involved in the transcriptional regulation of CCR5. Using in vitro assays, we determined that neither IRF-1 nor NF-kappaB is involved in the activation of the CCR5 promoter. This is corroborated by the finding that these factors are not involved in the induction of endogenous CCR5 transcription in various cell types. In contrast, we show that CCR5 expression is regulated by the cAMP/CREB pathway and that interference in this pathway affects endogenous CCR5 transcription. From this, we conclude that the cAMP/CREB pathway is involved in the regulation of CCR5 transcription and that, given the ubiquitous nature of CREB-1 protein expression, additional regulatory mechanisms must contribute to cell type-specific expression of CCR5.
Similar articles
- Transcriptional regulation of the chemokine co-receptor CCR5 by the cAMP/PKA/CREB pathway.
Banerjee A, Pirrone V, Wigdahl B, Nonnemacher MR. Banerjee A, et al. Biomed Pharmacother. 2011 Jul;65(4):293-7. doi: 10.1016/j.biopha.2011.03.009. Epub 2011 May 30. Biomed Pharmacother. 2011. PMID: 21719243 Free PMC article. - Leptin augments recruitment of IRF-1 and CREB to thrombospondin-1 gene promoter in vascular smooth muscle cells in vitro.
Sahu S, Ganguly R, Raman P. Sahu S, et al. Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C212-24. doi: 10.1152/ajpcell.00068.2016. Epub 2016 Jun 8. Am J Physiol Cell Physiol. 2016. PMID: 27281481 - Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors.
Wierda RJ, Kuipers HF, van Eggermond MC, Benard A, van Leeuwen JC, Carluccio S, Geutskens SB, Jukema JW, Marquez VE, Quax PH, van den Elsen PJ. Wierda RJ, et al. J Cell Mol Med. 2012 Aug;16(8):1866-77. doi: 10.1111/j.1582-4934.2011.01482.x. J Cell Mol Med. 2012. PMID: 22050776 Free PMC article. - Is the CCR5 Δ 32 mutation associated with immune system-related diseases?
Ghorban K, Dadmanesh M, Hassanshahi G, Momeni M, Zare-Bidaki M, Arababadi MK, Kennedy D. Ghorban K, et al. Inflammation. 2013 Jun;36(3):633-42. doi: 10.1007/s10753-012-9585-8. Inflammation. 2013. PMID: 23250822 Review.
Cited by
- Targeting C-C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke.
Feng YQ, Xu ZZ, Wang YT, Xiong Y, Xie W, He YY, Chen L, Liu GY, Li X, Liu J, Wu Q. Feng YQ, et al. Front Cell Neurosci. 2022 Apr 28;16:876342. doi: 10.3389/fncel.2022.876342. eCollection 2022. Front Cell Neurosci. 2022. PMID: 35573839 Free PMC article. Review. - Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy.
Mohamed H, Gurrola T, Berman R, Collins M, Sariyer IK, Nonnemacher MR, Wigdahl B. Mohamed H, et al. Front Immunol. 2022 Jan 20;12:816515. doi: 10.3389/fimmu.2021.816515. eCollection 2021. Front Immunol. 2022. PMID: 35126374 Free PMC article. Review. - CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest.
Chen Z, Xie X, Jiang N, Li J, Shen L, Zhang Y. Chen Z, et al. Cell Death Dis. 2021 Feb 15;12(2):184. doi: 10.1038/s41419-021-03464-7. Cell Death Dis. 2021. PMID: 33589608 Free PMC article. - Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.
Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung'u T, Hunt PW, He W, Ahuja SK. Gornalusse GG, et al. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4762-71. doi: 10.1073/pnas.1423228112. Epub 2015 Aug 11. Proc Natl Acad Sci U S A. 2015. PMID: 26307764 Free PMC article. - The frequency of CCR5 promoter polymorphisms and CCR5 Δ 32 mutation in Iranian populations.
Zare-Bidaki M, Karimi-Googheri M, Hassanshahi G, Zainodini N, Arababadi MK. Zare-Bidaki M, et al. Iran J Basic Med Sci. 2015 Apr;18(4):312-6. Iran J Basic Med Sci. 2015. PMID: 26019792 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials