Recent insights into the biology and biomedical applications of Flock House virus - PubMed (original) (raw)

Review

Recent insights into the biology and biomedical applications of Flock House virus

P A Venter et al. Cell Mol Life Sci. 2008 Sep.

Abstract

Flock House virus (FHV) is a nonenveloped, icosahedral insect virus whose genome consists of two molecules of single-stranded, positive-sense RNA. FHV is a highly tractable system for studies on a variety of basic aspects of RNA virology. In this review, recent studies on the replication of FHV genomic and subgenomic RNA are discussed, including a landmark study on the ultrastructure and molecular organization of FHV replication complexes. In addition, we show how research on FHV B2, a potent suppressor of RNA silencing, resulted in significant insights into antiviral immunity in insects. We also explain how the specific packaging of the bipartite genome of this virus is not only controlled by specific RNA-protein interactions but also by coupling between RNA replication and genome recognition. Finally, applications for FHV as an epitopepresenting system are described with particular reference to its recent use for the development of a novel anthrax antitoxin and vaccine.

PubMed Disclaimer

Cited by

Ultrastructure of the replication sites of positive-strand RNA viruses.
Harak C, Lohmann V. Harak C, et al. Virology. 2015 May;479-480:418-33. doi: 10.1016/j.virol.2015.02.029. Epub 2015 Mar 6. Virology. 2015. PMID: 25746936 Free PMC article. Review.
Mapping RNA-capsid interactions and RNA secondary structure within virus particles using next-generation sequencing.
Zhou Y, Routh A. Zhou Y, et al. Nucleic Acids Res. 2020 Jan 24;48(2):e12. doi: 10.1093/nar/gkz1124. Nucleic Acids Res. 2020. PMID: 31799606 Free PMC article.
RNA virus-mediated changes in organismal oxygen consumption rate in young and old Drosophila melanogaster males.
Hagedorn E, Bunnell D, Henschel B, Smith DL, Dickinson S, Brown AW, De Luca M, Turner AN, Chtarbanova S. Hagedorn E, et al. Aging (Albany NY). 2023 Mar 22;15(6):1748-1767. doi: 10.18632/aging.204593. Epub 2023 Mar 22. Aging (Albany NY). 2023. PMID: 36947702 Free PMC article.
The self-interaction of a nodavirus replicase is enhanced by mitochondrial membrane lipids.
Qiu Y, Wang Z, Liu Y, Han Y, Miao M, Qi N, Yang J, Xia H, Li X, Qin CF, Hu Y, Zhou X. Qiu Y, et al. PLoS One. 2014 Feb 25;9(2):e89628. doi: 10.1371/journal.pone.0089628. eCollection 2014. PLoS One. 2014. PMID: 24586921 Free PMC article.
Limits of variation, specific infectivity, and genome packaging of massively recoded poliovirus genomes.
Song Y, Gorbatsevych O, Liu Y, Mugavero J, Shen SH, Ward CB, Asare E, Jiang P, Paul AV, Mueller S, Wimmer E. Song Y, et al. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8731-E8740. doi: 10.1073/pnas.1714385114. Epub 2017 Sep 25. Proc Natl Acad Sci U S A. 2017. PMID: 28973853 Free PMC article.

Recent insights into the biology and biomedical applications of Flock House virus - PubMed (original) (raw)