Crucial role of interleukin-4 in the survival of colon cancer stem cells - PubMed (original) (raw)
Review
Crucial role of interleukin-4 in the survival of colon cancer stem cells
Maria Giovanna Francipane et al. Cancer Res. 2008.
Abstract
Colon tumors may be maintained by a rare fraction of cancer stem-like cells (CSC) that express the cell surface marker CD133. Self-renewing CSCs exhibit relatively greater resistance to clinical cytotoxic therapies and recent work suggests that this resistance may be mediated in part by an autocrine response to the immune cytokine interleukin 4 (IL-4). Blocking IL-4 signaling can sensitize CSCs to apoptotic stimuli and increase the in vivo efficacy of cytotoxic therapy. These findings suggest that inhibitors of IL-4 signaling may offer a new therapeutic tool in colon carcinoma.
Similar articles
- Interleukin-12 inhibits the survival of human colon cancer stem cells in vitro and their tumor initiating capacity in mice.
Yin XL, Wang N, Wei X, Xie GF, Li JJ, Liang HJ. Yin XL, et al. Cancer Lett. 2012 Sep 1;322(1):92-7. doi: 10.1016/j.canlet.2012.02.015. Epub 2012 Feb 22. Cancer Lett. 2012. PMID: 22366581 - Apoptosis signaling in cancer stem cells.
Fulda S, Pervaiz S. Fulda S, et al. Int J Biochem Cell Biol. 2010 Jan;42(1):31-8. doi: 10.1016/j.biocel.2009.06.010. Epub 2009 Jul 3. Int J Biochem Cell Biol. 2010. PMID: 19577660 Review. - Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes.
Todaro M, D'Asaro M, Caccamo N, Iovino F, Francipane MG, Meraviglia S, Orlando V, La Mendola C, Gulotta G, Salerno A, Dieli F, Stassi G. Todaro M, et al. J Immunol. 2009 Jun 1;182(11):7287-96. doi: 10.4049/jimmunol.0804288. J Immunol. 2009. PMID: 19454726 - Die hard: are cancer stem cells the Bruce Willises of tumor biology?
Fábián A, Barok M, Vereb G, Szöllosi J. Fábián A, et al. Cytometry A. 2009 Jan;75(1):67-74. doi: 10.1002/cyto.a.20690. Cytometry A. 2009. PMID: 19051297 Review. - Current status and issues in cancer stem cell study.
Yang YM, Chang JW. Yang YM, et al. Cancer Invest. 2008 Aug;26(7):741-55. doi: 10.1080/07357900801901856. Cancer Invest. 2008. PMID: 18608212 Review.
Cited by
- Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting.
Guo Q, Zhou Y, Xie T, Yuan Y, Li H, Shi W, Zheng L, Li X, Zhang W. Guo Q, et al. Genes Dis. 2023 Jul 19;11(3):101043. doi: 10.1016/j.gendis.2023.05.024. eCollection 2024 May. Genes Dis. 2023. PMID: 38292177 Free PMC article. Review. - Gradient Boosting Machine Identified Predictive Variables for Breast Cancer Patients Pre- and Post-Radiotherapy: Preliminary Results of an 8-Year Follow-Up Study.
Rodríguez-Tomàs E, Arenas M, Baiges-Gaya G, Acosta J, Araguas P, Malave B, Castañé H, Jiménez-Franco A, Benavides-Villarreal R, Sabater S, Solà-Alberich R, Camps J, Joven J. Rodríguez-Tomàs E, et al. Antioxidants (Basel). 2022 Dec 2;11(12):2394. doi: 10.3390/antiox11122394. Antioxidants (Basel). 2022. PMID: 36552602 Free PMC article. - Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications.
Cui G, Wang Z, Liu H, Pang Z. Cui G, et al. Front Immunol. 2022 Nov 17;13:1057181. doi: 10.3389/fimmu.2022.1057181. eCollection 2022. Front Immunol. 2022. PMID: 36466926 Free PMC article. Review. - Characterization of Immunogenicity of Malignant Cells with Stemness in Intrahepatic Cholangiocarcinoma by Single-Cell RNA Sequencing.
Bian J, Fu J, Wang X, Lee J, Brar G, Escorcia FE, Cam M, Xie C. Bian J, et al. Stem Cells Int. 2022 Apr 29;2022:3558200. doi: 10.1155/2022/3558200. eCollection 2022. Stem Cells Int. 2022. PMID: 35530414 Free PMC article. - Effect of resveratrol on drug resistance in colon cancer chemotherapy.
Huang L, Zhang S, Zhou J, Li X. Huang L, et al. RSC Adv. 2019 Jan 18;9(5):2572-2580. doi: 10.1039/c8ra08364a. eCollection 2019 Jan 18. RSC Adv. 2019. PMID: 35520503 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials