Vascular calcification: pathobiology of a multifaceted disease - PubMed (original) (raw)
Review
Vascular calcification: pathobiology of a multifaceted disease
Linda L Demer et al. Circulation. 2008.
No abstract available
Figures
Fig. 1
Schematic representation of selected regulatory factors and their possible roles in vascular biomineralization. Inorganic phosphate (Pi) translocates via Pit-1 to the cytoplasm. Cytoplasmic Ca++ and Pi incorporate with ALP into matrix vesicles, which bud off the plasma membrane and associate with extracellular proteins, such as collagen. NPP1 generates the mineralization inhibitor, pyrophosphate (PPi), which is inhibited by alkaline phosphatase. Some important factors have not been shown for clarity. Dashed arrows indicate translocation, solid-line arrows indicate induction, solid line bars indicate inhibition. Abbreviations: ALP, alkaline phosphatase; BMP, bone morphogenetic protein; BSP, bone sialoprotein; MGP, matrix Gla protein; NPP1, ectonucleotide pyrophosphatasephosphodiesterease1; OPG, osteoprotegerin; OPN, osteopontin; OCN, osteocalcin; Pi, inorganic phosphate; Pit-1, type III sodium-dependent phosphate cotransporter; PPi, pyrophosphate; PKA, protein kinase A; PTH, parathyroid hormone; ROS, reactive oxygen species.
Fig. 2
Calcified nodules in vivo and in vitro. (A) Calcific aortic stenosis (Image kindly provided by Dr. Michael Fishbein, UCLA Pathology; horizontal dimension ~4 cm) and (B) Dilutionally-cloned vascular smooth muscle cells (horizontal dimension ~1 cm). The nodules correspond in shape, size, and content.
Fig. 2
Calcified nodules in vivo and in vitro. (A) Calcific aortic stenosis (Image kindly provided by Dr. Michael Fishbein, UCLA Pathology; horizontal dimension ~4 cm) and (B) Dilutionally-cloned vascular smooth muscle cells (horizontal dimension ~1 cm). The nodules correspond in shape, size, and content.
Similar articles
- Vascular calcification and its relation to bone calcification: possible underlying mechanisms.
Mody N, Tintut Y, Radcliff K, Demer LL. Mody N, et al. J Nucl Cardiol. 2003 Mar-Apr;10(2):177-83. doi: 10.1067/mnc.2003.0012. J Nucl Cardiol. 2003. PMID: 12673183 Review. No abstract available. - Metabolic acidosis and vascular calcification: using blueprints from bone to map a new venue for vascular research.
Al-Aly Z. Al-Aly Z. Kidney Int. 2008 Feb;73(4):377-9. doi: 10.1038/sj.ki.5002738. Kidney Int. 2008. PMID: 18235519 - Thematic series on the pathobiology of vascular calcification: an introduction.
Towler DA, Demer LL. Towler DA, et al. Circ Res. 2011 May 27;108(11):1378-80. doi: 10.1161/CIRCRESAHA.110.234419. Circ Res. 2011. PMID: 21617134 Free PMC article. Review. - [Vascular calcification: is there a link between hyperphosphatemia and hyperglycemia?].
Cozzolino M. Cozzolino M. G Ital Nefrol. 2008 May-Jun;25(3):271. G Ital Nefrol. 2008. PMID: 18473292 Italian. No abstract available. - Mechanisms of vascular calcification in chronic kidney disease.
Moe SM, Chen NX. Moe SM, et al. J Am Soc Nephrol. 2008 Feb;19(2):213-6. doi: 10.1681/ASN.2007080854. Epub 2007 Dec 19. J Am Soc Nephrol. 2008. PMID: 18094365 Review.
Cited by
- Arterial calcification and bone physiology: role of the bone-vascular axis.
Thompson B, Towler DA. Thompson B, et al. Nat Rev Endocrinol. 2012 Sep;8(9):529-43. doi: 10.1038/nrendo.2012.36. Epub 2012 Apr 3. Nat Rev Endocrinol. 2012. PMID: 22473330 Free PMC article. Review. - Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis.
Jäger E, Murthy S, Schmidt C, Hahn M, Strobel S, Peters A, Stäubert C, Sungur P, Venus T, Geisler M, Radusheva V, Raps S, Rothe K, Scholz R, Jung S, Wagner S, Pierer M, Seifert O, Chang W, Estrela-Lopis I, Raulien N, Krohn K, Sträter N, Hoeppener S, Schöneberg T, Rossol M, Wagner U. Jäger E, et al. Nat Commun. 2020 Aug 25;11(1):4243. doi: 10.1038/s41467-020-17749-6. Nat Commun. 2020. PMID: 32843625 Free PMC article. - The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection.
Duplancic D, Cesarik M, Poljak NK, Radman M, Kovacic V, Radic J, Rogosic V. Duplancic D, et al. Clin Interv Aging. 2013;8:149-56. doi: 10.2147/CIA.S38349. Epub 2013 Feb 11. Clin Interv Aging. 2013. PMID: 23430986 Free PMC article. Review. - In vitro/In vivo Evaluations of Hydroxyapatite Nanoparticles with Different Geometry.
Sun W, Zhong J, Gao B, Feng J, Ye Z, Lin Y, Zhang K, Su W, Zhu S, Li Y, Jia W. Sun W, et al. Int J Nanomedicine. 2024 Aug 23;19:8661-8679. doi: 10.2147/IJN.S469687. eCollection 2024. Int J Nanomedicine. 2024. PMID: 39193530 Free PMC article. - Vascular Adventitia Calcification and Its Underlying Mechanism.
Li N, Cheng W, Huang T, Yuan J, Wang X, Song M. Li N, et al. PLoS One. 2015 Jul 6;10(7):e0132506. doi: 10.1371/journal.pone.0132506. eCollection 2015. PLoS One. 2015. PMID: 26148272 Free PMC article.
References
- Allison MA, Criqui MH, Wright CM. Patterns and risk factors for systemic calcified atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:331–6. - PubMed
- Wayhs R, Zelinger A, Raggi P. High coronary artery calcium scores pose an extremely elevated risk for hard events. J Am Coll Cardiol. 2002;39:225–30. - PubMed
- Arad Y, Spadaro LA, Goodman K, Newstein D, Guerci AD. Prediction of coronary events with electron beam computed tomography. J Am Coll Cardiol. 2000;36:1253–60. - PubMed
- Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA, Sheedy IP, Peyser PA, Schwartz RS. Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation. 2001;104:412–7. - PubMed
- Kelly RP, Tunin R, Kass DA. Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricle. Circ Res. 1992;71:490–502. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical