Bone and fat connection in aging bone - PubMed (original) (raw)
Review
Bone and fat connection in aging bone
Gustavo Duque. Curr Opin Rheumatol. 2008 Jul.
Abstract
Purpose of review: The fat and bone connection plays an important role in the pathophysiology of age-related bone loss. This review will focus on the age-induced mechanisms regulating the predominant differentiation of mesenchymal stem cells into adipocytes. Additionally, bone marrow fat will be considered as a diagnostic and therapeutic approach to osteoporosis.
Recent findings: There are two types of bone and fat connection. The 'systemic connection', usually seen in obese patients, is hormonally regulated and associated with high bone mass and strength. The 'local connection' happens inside the bone marrow. Increasing amounts of bone marrow fat affect bone turnover through the inhibition of osteoblast function and survival and the promotion of osteoclast differentiation and activation. This interaction is regulated by paracrine secretion of fatty acids and adipokines. Additionally, bone marrow fat could be quantified using noninvasive methods and could be used as a therapeutic approach due to its capacity to transdifferentiate into bone without affecting other types of fat in the body.
Summary: The bone and fat connection within the bone marrow constitutes a typical example of lipotoxicity. Additionally, bone marrow fat could be used as a new diagnostic and therapeutic approach for osteoporosis in older persons.
Similar articles
- Playing with bone and fat.
Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME. Gimble JM, et al. J Cell Biochem. 2006 May 15;98(2):251-66. doi: 10.1002/jcb.20777. J Cell Biochem. 2006. PMID: 16479589 Review. - Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome.
Duque G, Troen BR. Duque G, et al. J Am Geriatr Soc. 2008 May;56(5):935-41. doi: 10.1111/j.1532-5415.2008.01764.x. J Am Geriatr Soc. 2008. PMID: 18454751 Review. - [Drugs influencing bone metabolism in diabetic patients].
Palicka V. Palicka V. Vnitr Lek. 2009 Apr;55(4):368-70. Vnitr Lek. 2009. PMID: 19449752 Czech. - Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis.
Rosen CJ, Klibanski A. Rosen CJ, et al. Am J Med. 2009 May;122(5):409-14. doi: 10.1016/j.amjmed.2008.11.027. Am J Med. 2009. PMID: 19375545 Review. - Senescence-associated intrinsic mechanisms of osteoblast dysfunctions.
Kassem M, Marie PJ. Kassem M, et al. Aging Cell. 2011 Apr;10(2):191-7. doi: 10.1111/j.1474-9726.2011.00669.x. Epub 2011 Feb 18. Aging Cell. 2011. PMID: 21210937 Review.
Cited by
- Differential Responses to Aging Among the Transcriptome and Proteome of Mesenchymal Progenitor Populations.
Feehan J, Tripodi N, Kondrikov D, Wijeratne T, Gimble J, Hill W, Apostolopoulos V, Duque G. Feehan J, et al. J Gerontol A Biol Sci Med Sci. 2024 Sep 1;79(9):glae147. doi: 10.1093/gerona/glae147. J Gerontol A Biol Sci Med Sci. 2024. PMID: 38837176 Free PMC article. - Predictive factors of bone strength variation in adolescent girls according to body composition.
Khwanchuea R. Khwanchuea R. Ann Pediatr Endocrinol Metab. 2024 Apr;29(2):119-129. doi: 10.6065/apem.2346122.061. Epub 2024 Apr 30. Ann Pediatr Endocrinol Metab. 2024. PMID: 38712493 Free PMC article. - Role of extracellular vesicles associated with microRNAs and their interplay with cuproptosis in osteoporosis.
Sun Y, Chen P, Zhao B. Sun Y, et al. Noncoding RNA Res. 2024 Mar 13;9(3):715-719. doi: 10.1016/j.ncrna.2024.03.002. eCollection 2024 Sep. Noncoding RNA Res. 2024. PMID: 38577024 Free PMC article. Review. - Linking bone marrow fat with decreased bone mineral density among Indian patients with osteoporotic fracture.
Paranthaman M, Angu Bala Ganesh KSV, Silambanan S. Paranthaman M, et al. Bioinformation. 2024 Jan 31;20(1):49-54. doi: 10.6026/973206300200049. eCollection 2024. Bioinformation. 2024. PMID: 38352899 Free PMC article. - Differential responses to aging amongst the transcriptome and proteome of mesenchymal progenitor populations.
Duque G, Feehan J, Tripodi N, Kondrikov D, Wijeratne T, Gimble J, Hill W, Apostolopoulos V. Duque G, et al. Res Sq [Preprint]. 2023 Dec 15:rs.3.rs-3755129. doi: 10.21203/rs.3.rs-3755129/v1. Res Sq. 2023. PMID: 38168272 Free PMC article. Updated. Preprint.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials