Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois - PubMed (original) (raw)
Review
. 2008 Jun 12;3(6):344-7.
doi: 10.1016/j.chom.2008.05.010.
Affiliations
- PMID: 18541210
- DOI: 10.1016/j.chom.2008.05.010
Free article
Review
Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois
Thierry Pédron et al. Cell Host Microbe. 2008.
Free article
Abstract
According to a classical view of bacterial-host interactions at intestinal surfaces, the commensal microbiota establishes tolerance, and invasive pathogens cause stereotypic inflammation. The reality is more complex, marked by a "ménage à trois" situation encompassing three emerging concepts: (1) pathogens take advantage of inflammation to cross the epithelial barrier, (2) pathogens reduce the commensal flora to invade their niche, and (3) pathogens express dedicated effectors that modulate inflammation.