Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps - PubMed (original) (raw)
Review
Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps
L David Sibley et al. Annu Rev Microbiol. 2008.
Abstract
Toxoplasma gondii is among the most successful parasites. It is capable of infecting all warm-blooded animals and causing opportunistic disease in humans. T. gondii has a striking clonal population structure consisting of three predominant lineages in North America and Europe. Clonality is associated with the recent emergence of a monomorphic version of Chr1a, which drove a selective genetic sweep within the past 10,000 years. Strains from South America diverged from those in North America some 1-2 mya; recently, however, the monomorphic Chr1a has extended into regions of South America, where it is also associated with clonality. The recent spread of a few dominant lineages has dramatically shaped the population structure of T. gondii and has resulted in most lineages sharing a highly pathogenic nature. Understanding the factors that have shaped the population structure of T. gondii has implications for the emergence and transmission of human pathogens.
Similar articles
- Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome.
Khan A, Fux B, Su C, Dubey JP, Darde ML, Ajioka JW, Rosenthal BM, Sibley LD. Khan A, et al. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14872-7. doi: 10.1073/pnas.0702356104. Epub 2007 Sep 5. Proc Natl Acad Sci U S A. 2007. PMID: 17804804 Free PMC article. - A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii.
Khan A, Miller N, Roos DS, Dubey JP, Ajzenberg D, Dardé ML, Ajioka JW, Rosenthal B, Sibley LD. Khan A, et al. mBio. 2011 Nov 8;2(6):e00228-11. doi: 10.1128/mBio.00228-11. Print 2011. mBio. 2011. PMID: 22068979 Free PMC article. - Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity.
Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP. Minot S, et al. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13458-63. doi: 10.1073/pnas.1117047109. Epub 2012 Jul 30. Proc Natl Acad Sci U S A. 2012. PMID: 22847430 Free PMC article. - Sexual recombination punctuated by outbreaks and clonal expansions predicts Toxoplasma gondii population genetics.
Grigg ME, Sundar N. Grigg ME, et al. Int J Parasitol. 2009 Jul 1;39(8):925-33. doi: 10.1016/j.ijpara.2009.02.005. Epub 2009 Feb 13. Int J Parasitol. 2009. PMID: 19217909 Free PMC article. Review. - Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host.
Saeij JP, Boyle JP, Boothroyd JC. Saeij JP, et al. Trends Parasitol. 2005 Oct;21(10):476-81. doi: 10.1016/j.pt.2005.08.001. Trends Parasitol. 2005. PMID: 16098810 Review.
Cited by
- Modulation of innate immunity by Toxoplasma gondii virulence effectors.
Hunter CA, Sibley LD. Hunter CA, et al. Nat Rev Microbiol. 2012 Nov;10(11):766-78. doi: 10.1038/nrmicro2858. Nat Rev Microbiol. 2012. PMID: 23070557 Free PMC article. Review. - Neuroimmunology of Common Parasitic Infections in Africa.
Idro R, Ogwang R, Barragan A, Raimondo JV, Masocha W. Idro R, et al. Front Immunol. 2022 Feb 10;13:791488. doi: 10.3389/fimmu.2022.791488. eCollection 2022. Front Immunol. 2022. PMID: 35222377 Free PMC article. Review. - 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: darwinian medicine and the 'hygiene' or 'old friends' hypothesis.
Rook GA. Rook GA. Clin Exp Immunol. 2010 Apr;160(1):70-9. doi: 10.1111/j.1365-2249.2010.04133.x. Clin Exp Immunol. 2010. PMID: 20415854 Free PMC article. - Genotyping Toxoplasma gondii from wildlife in Pennsylvania and identification of natural recombinants virulent to mice.
Dubey JP, Van Why K, Verma SK, Choudhary S, Kwok OC, Khan A, Behinke MS, Sibley LD, Ferreira LR, Oliveira S, Weaver M, Stewart R, Su C. Dubey JP, et al. Vet Parasitol. 2014 Feb 24;200(1-2):74-84. doi: 10.1016/j.vetpar.2013.11.001. Epub 2013 Nov 14. Vet Parasitol. 2014. PMID: 24332401 Free PMC article. - Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon.
Fox BA, Guevara RB, Rommereim LM, Falla A, Bellini V, Pètre G, Rak C, Cantillana V, Dubremetz JF, Cesbron-Delauw MF, Taylor GA, Mercier C, Bzik DJ. Fox BA, et al. mBio. 2019 Jul 2;10(4):e00589-19. doi: 10.1128/mBio.00589-19. mBio. 2019. PMID: 31266861 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous