IL-21 and autoimmune disease--hypothesis and reality? - PubMed (original) (raw)
Comment
IL-21 and autoimmune disease--hypothesis and reality?
Rikard Holmdahl. Eur J Immunol. 2008 Jul.
Free article
Abstract
Previous data have indicated that IL-21 and/or IL-21R are crucial for the differentiation of naïve T cells into Th17 cells and also play a key role in the development of autoimmune disease. Given this, IL-21 and/or IL-21R are potential targets for therapy of such diseases; however, a study in this issue of the European Journal of Immunology, provides a new twist in the story as it is now shown that IL-21 and/or IL-21R play no role in Th17 development or autoimmune inflammatory disease. The reasons for these contradictory data are discussed in this Commentary.
Comment on
- IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo.
Sonderegger I, Kisielow J, Meier R, King C, Kopf M. Sonderegger I, et al. Eur J Immunol. 2008 Jul;38(7):1833-8. doi: 10.1002/eji.200838511. Eur J Immunol. 2008. PMID: 18546146
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