Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses - PubMed (original) (raw)

. 2008 Jul 4;26(29-30):3574-9.

doi: 10.1016/j.vaccine.2008.05.011. Epub 2008 May 27.

Affiliations

• PMID: 18547691
• DOI: 10.1016/j.vaccine.2008.05.011

Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses

Gareth Baynam et al. Vaccine. 2008.

Abstract

Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Ralpha I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p=0.01, TetTox p=0.04; IL-4Ralpha.I50V: DipTox p=0.04, TetTox p=0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p=0.03) and TetTox (p=0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p=0.01) and IL-4Ralpha I50V (p=0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses.

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